Tryptophan hydroxylase 2 Products

Antibodies
Tryptophan hydroxylase 2 Anti ...
Tryptophan hydroxylase 2 Antibody
NB100-74555
Species: Hu, Mu, Rt, Pm, Rb
Applications: WB, ICC/IF, IHC, IHC-P, IP, IHC-FrFl
Host: Rabbit Polyclonal
Tryptophan hydroxylase 2 Anti ...
Tryptophan hydroxylase 2 Antibody ...
NBP2-46646
Species: Hu, Mu, Rt
Applications: IHC
Host: Mouse Monoclonal
RNAi
Tryptophan hydroxylase 2 RNAi ...
Tryptophan hydroxylase 2 RNAi
H00121278-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Tryptophan hydroxylase (TPH) catalyzes the 5-hydroxylation of tryptophan, which is the first step in the biosynthesis of indoleamines (serotonin and melatonin) (Martinez et al., 2001). In mammals, serotonin biosynthesis occurs predominantly in neurons which originate in the Raphe nuclei of the brain, and melatonin synthesis takes place within the pineal gland. Although TPH catalyzes the same reaction within the Raphe nuclei and the pineal gland, TPH activity is rate-limiting for serotonin but not melatonin biosynthesis. Serotonin functions mainly as a neurotransmitter, whereas melatonin is the principal hormone secreted by the pineal gland. The activity of TPH is enhanced by phosphorylation by cAMP-dependent protein kinase (PKA) and Ca2+/calmodulin kinase II (CaM K II) (Jiang et al., 2000; Johansen et al., 1996). CaM K II phosphorylates Ser260 which lies within the regulatory domain of TPH (Jiang et al., 2000).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Product By Gene ID 121278
Alternate Names
  • EC 1.14.16.4
  • EC 1.14.16
  • Tryptophan 5-monooxygenase 2
  • tryptophan 5-hydroxylase 2
  • Neuronal tryptophan hydroxylase
  • MGC138872
  • FLJ37295
  • NTPHMGC138871
  • ADHD7
  • tryptophan hydroxylase 2

Research Areas for Tryptophan hydroxylase 2

Find related products by research area and learn more about each of the different research areas below.

Lipid and Metabolism
Phospho-Specific

PTMs for Tryptophan hydroxylase 2

Learn more about PTMs related to Tryptophan hydroxylase 2.

Phosphorylation
Hydroxylation
Cleavage
Decarboxylation
Oxidation
Methylation

Bioinformatics Tool for Tryptophan hydroxylase 2

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