TRPM4 Products

TRPM4 Overexpression Lysate
TRPM4 Overexpression Lysate
Species: Hu
Applications: WB
TRPM4 Recombinant Protein Ant ...
TRPM4 Recombinant Protein Antigen
Species: Hu
Applications: AC


FUNCTION: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload.; ENZYME REGULATION: Gating is voltage-dependent and repressed by decavanadate. Calmodulin-binding confers the Ca(2+) sensitivity. ATP is able to restore Ca(2+) sensitivity after desensitization. Phosphatidylinositol 4,5-biphosphate (PIP2)-binding strongly enhances activity, by increasing the channel's Ca(2+) sensitivity and shifting its voltage dependence of activation towards negative potentials. Activity is also enhanced by 3,5-bis(trifluoromethyl)pyrazole derivative (BTP2). SUBUNIT: Homomultimer. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Widely expressed with a high expression in intestine and prostate. In brain, it is both expressed in whole cerebral arteries and isolated vascular smooth muscle cells.


Entrez Human
Uniprot Human
Product By Gene ID 54795
Alternate Names
  • PFHB1B
  • Melastatin-4
  • hTRPM4
  • LTrpC-4
  • LTrpC4
  • LTRPC4
  • Long transient receptor potential channel 4
  • transient receptor potential cation channel subfamily M member 4
  • Calcium-activated non-selective cation channel 1
  • melastatin-4
  • FLJ20041
  • TRPM4B
  • transient receptor potential cation channel, subfamily M, member 4

PTMs for TRPM4

Learn more about PTMs related to TRPM4.


Bioinformatics Tool for TRPM4

Discover related pathways, diseases and genes to TRPM4. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Related TRPM4 Blog Posts

Check out the latest blog posts on TRPM4.
Winter is coming, and TRPM8 welcomes the cold!
TRPM8, or transient receptor potential melastatin 8, is a nonselective cation channel that is activated by cold environments and menthol-like cooling compounds.  While TRPM8 is best known for its location in peripheral nerve endings, it has functio...    Read more.
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