TRPM4 Products

Antibodies
TRPM4 Antibody (10H5)
TRPM4 Antibody (10H5)
NBP1-48036
Species: Hu, Ca, Pm
Applications: WB, IHC, IHC-P
Host: Mouse Monoclonal
TRPM4 Antibody
TRPM4 Antibody
NBP2-13487
Species: Hu, Mouse, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
TRPM4 Antibody
TRPM4 Antibody
NB110-74949
Species: Mu, Rt
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
TRPM4 Overexpression Lysate ( ...
TRPM4 Overexpression Lysate (Native)
NBL1-17336
Applications: WB
Proteins
TRPM4 Recombinant Protein Ant ...
TRPM4 Recombinant Protein Antigen
NBP2-13487PEP
Species: Hu
Applications: AC
RNAi
TRPM4 RNAi
TRPM4 RNAi
H00054795-R01
Species: Hu

Description

FUNCTION: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload.; ENZYME REGULATION: Gating is voltage-dependent and repressed by decavanadate. Calmodulin-binding confers the Ca(2+) sensitivity. ATP is able to restore Ca(2+) sensitivity after desensitization. Phosphatidylinositol 4,5-biphosphate (PIP2)-binding strongly enhances activity, by increasing the channel's Ca(2+) sensitivity and shifting its voltage dependence of activation towards negative potentials. Activity is also enhanced by 3,5-bis(trifluoromethyl)pyrazole derivative (BTP2). SUBUNIT: Homomultimer. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Widely expressed with a high expression in intestine and prostate. In brain, it is both expressed in whole cerebral arteries and isolated vascular smooth muscle cells.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Rat
Product By Gene ID 54795
Alternate Names
  • PFHB1B
  • Melastatin-4
  • hTRPM4
  • LTrpC-4
  • LTrpC4
  • LTRPC4
  • Long transient receptor potential channel 4
  • transient receptor potential cation channel subfamily M member 4
  • Calcium-activated non-selective cation channel 1
  • melastatin-4
  • FLJ20041
  • TRPM4B
  • transient receptor potential cation channel, subfamily M, member 4

PTMs for TRPM4

Learn more about PTMs related to TRPM4.

Phosphorylation
Sumoylation
Biotinylation
Ubiquitination

Bioinformatics Tool for TRPM4

Discover related pathways, diseases and genes to TRPM4. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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