TRAF-3 Products

Antibodies
TRAF-3 Antibody
TRAF-3 Antibody
NB100-56654
Species: Hu, Mu
Applications: WB, IHC-P
Host: Rabbit Polyclonal
TRAF-3 Antibody
TRAF-3 Antibody
NB100-56176
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
TRAF-3 Antibody
TRAF-3 Antibody
NBP1-86639
Species: Hu, Mu, Rt, Mouse, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
TRAF-3 Overexpression Lysate ...
TRAF-3 Overexpression Lysate (Dena...
H00007187-T01
Species: Hu
Applications: WB
TRAF-3 Overexpression Lysate ...
TRAF-3 Overexpression Lysate (Native)
NBL1-17241
Applications: WB
TRAF-3 Overexpression Lysate ...
TRAF-3 Overexpression Lysate (Native)
NBL1-17242
Applications: WB
Proteins
TRAF-3 Recombinant Protein
TRAF-3 Recombinant Protein
H00007187-P01
Species: Hu
Applications: WB, ELISA, PA
TRAF-3 Partial Recombinant Pr ...
TRAF-3 Partial Recombinant Protein
H00007187-Q01
Species: Hu
Applications: WB, ELISA, PA
TRAF-3 Recombinant Protein An ...
TRAF-3 Recombinant Protein Antigen
NBP1-86639PEP
Species: Hu
Applications: AC
RNAi
TRAF-3 RNAi
TRAF-3 RNAi
H00007187-R03
Species: Hu
TRAF-3 RNAi
TRAF-3 RNAi
H00007187-R01
Species: Hu
TRAF-3 RNAi
TRAF-3 RNAi
H00007187-R02
Species: Hu

Description

Human TRAF-3 is a signaling molecule that interacts with the cytoplasmic tails of CD40 and other TNF-receptor family members (1). The TNF-receptor-associated factor (TRAF) family is a phylogenetically conserved group of scaffold proteins that link receptors of the IL-1R/Toll and TNF receptor family to signalling cascades, leading to the activation of NF-kappaB and mitogen-activated protein kinases. Furthermore, TRAF proteins serve as a docking platform for a variety of regulators of these signaling pathways and are themselves often regulated at the transcriptional and posttranslational level (2). The CD40 fragment binds as a hairpin loop across the surface of the TRAF domain. Residues shown by mutagenesis and deletion analysis to be critical for TRAF3 binding are involved either in direct contact with TRAF3 or in intramolecular interactions that stabilize the hairpin (3).

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 7187
Alternate Names
  • CD40 associated protein 1
  • CD40-binding protein
  • LMP1-associated protein 1
  • CD40 receptor-associated factor 1
  • CD40bp
  • LAP1CD40BP
  • CRAF1CAP1
  • CAP-1CD40 receptor associated factor 1
  • CD40 binding protein
  • TNF receptor-associated factor 3

Research Areas for TRAF-3

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Immunology
Innate Immunity
Zinc Finger

Bioinformatics Tool for TRAF-3

Discover related pathways, diseases and genes to TRAF-3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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