TLR5 Products

Description

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene product is expressed in myelomonocytic cells, and recognizes bacterial flagellin, a principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB and stimulates tumour necrosis factor-alpha production.

Bioinformatics

Entrez	7100 Human
Uniprot	NP_003259
Product By Gene ID	7100
Alternate Names	MGC126430 MGC126431 SLEB1FLJ10052 TIL-3 TIL3Toll/interleukin-1 receptor-like protein 3 TLR5 toll-like receptor 5

Research Areas for TLR5

Find related products by research area and learn more about each of the different research areas below.

Immunology
Innate Immunity
Prostate Cancer

Related TLR5 Blog Posts

Check out the latest blog posts on TLR5.

Toll-like receptors in the intestinal epithelial cells By Jamshed Arslan, Pharm. D., PhD. Toll-like receptors (TLRs) are microbe-sensing proteins that act as first responders to danger signals. TLRs help the intestinal epithelial cells (IECs) recognize commensal bacteria ...    Read more.

The role of TLR4 in breast cancer Toll like receptors (TLRs) are highly conserved proteins that are first known for their role in pathogen recognition and immune response activation.  In order to elicit the necessary immune response in reaction to a foreign pathogen, TLRs trigger cy...    Read more.

Read more TLR5 related blogs.