TAF15 Products

Description

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a subunit of TFIID present in a subset of TFIID complexes. Translocations involving chromosome 17 and chromosome 9, where the gene for the nuclear receptor CSMF is located, result in a gene fusion product that is an RNA binding protein associated with a subset of extraskeletal myxoid chondrosarcomas. Two transcripts encoding different isoforms have been identified.

Bioinformatics

Entrez	8148 Human
Uniprot	Q92804 Human
Product By Gene ID	8148
Alternate Names	68kDa hTAFII68 Npl3 RBP56TAFII68 RNA-binding protein 56 TAF(II)68 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor TAF2NRBP56/CSMF fusion TATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD(RNA-binding protein 56) TATA box-binding protein-associated factor 2N (RNA-binding protein 56) TATA-binding protein-associated factor 2N TBP-associated factor 15,68 kDa TATA-binding protein-associated factor

Research Areas for TAF15

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DNA Repair