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0695/50) prior to immersion fixation. Synaptotagmin-1 was detected using a Mouse Anti-Rat Synaptotagmin-1 Monoclonal Antibody (Catalog # MAB4364). The cells were stained with the NorthernLights 557-conjugated Donkey Anti-Mouse IgG Affinity-purified Secondary Antibody (red; Catalog # NL007). The cell nuclei were counterstained with DAPI (blue). Synaptotagmin-1 immunoreactivity was localized to synaptic vesicles in the cytoplasm and on the plasma membrane. View our protocol for Fluorescent ICC Staining of Cells on Coverslips." class="big_lightbox" target="_blank">
Synaptotagmin is widely regarded as the primary calcium sensor for synaptic vesicle exocytosis (Fernandez-Chacon et al., 2001; Wang et al., 2003). Moreover recent studies indicate that the protein also plays a key role in endocytosis (Poskanzer et al., 2003). Synaptotagmin can be phosphorylated by multiple protein kinases and this may play a key role in modulation of synaptotagmin ability to influence both the exocytotic and endocytotic components of synaptic transmission (Hilfiker et al., 1999; Lee et al., 2004).
![Immunocytochemistry Synaptotagmin 1 Antibody (ASV48) [Unconjugated]](http://images.novusbio.com/images/antibody/Synaptotagmin-1_MAB4364_Immunocytochemistry_11323.jpg)
![Immunohistochemistry Synaptotagmin 1 Antibody (ASV48) [Unconjugated]](http://images.novusbio.com/images/antibody/Synaptotagmin-1_MAB4364_Immunohistochemistry_7025.jpg)
![Immunocytochemistry Synaptotagmin 1 Antibody (ASV48) [Unconjugated]](http://images.novusbio.com/images/antibody/Synaptotagmin1_MAB4364_Immunocytochemistry_13008.jpg)
![Knockout Validated Synaptotagmin 1 Antibody (ASV48) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/mab4364_rat-synaptotagmin-1-mab-clone-asv48-knockout-validated-2862024122433..png)
![Immunoprecipitation Synaptotagmin 1 Antibody (ASV48) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/mab4364_rat-synaptotagmin-1-mab-clone-asv48-immunoprecipitation-2862024122559..png)
![Knockout Validated Synaptotagmin 1 Antibody (ASV48) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/mab4364_rat-synaptotagmin-1-mab-clone-asv48-knockout-validated-286202412275.jpg)
