STARD10 Products

Antibodies
STARD10 Antibody
STARD10 Antibody
NBP1-84508
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
STARD10 Antibody
STARD10 Antibody
NBP2-88368
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
STARD10 Antibody
STARD10 Antibody
NBP2-60729
Species: Hu
Applications: IP
Host: Rabbit Polyclonal
Lysates
STARD10 Overexpression Lysate ...
STARD10 Overexpression Lysate
NBL1-16517
Species: Hu
Applications: WB
Proteins
Recombinant Human STARD10 Pro ...
Recombinant Human STARD10 Protein
H00010809-P01
Species: Hu
Applications: WB, ELISA, PA, AP
STARD10 Recombinant Protein A ...
STARD10 Recombinant Protein Antigen
NBP1-84508PEP
Species: Hu
Applications: AC

Description

STARD10, STAR-related lipid transfer protein 10 or PCTP-like (33 kDa) is a transporter for lipids which specifically shuttles phosphatidylcholine and phosphatidylethanolamine between membranes. Mammalian STARD10 belongs to a family of fifteen START-domain proteins. In these family members, the carboxy terminal START-domain is conserved and functions in lipid binding or as a lipid sensing domain. The specificity for the type of lipid bound differs among family members (e.g., STARD1,3,5 binds Cholesterol, STARD5 binds 25-hydroxycholesterol, STARD2 binds phosphatidylcholine, and STARD11 binds ceramides). STARD proteins have been associated with various cellular processes such as lipid trafficking, lipid metabolism, and cell signaling (1, 2).

STARD10 is broadly expressed in different organs and tissues such as the brain, endocrine tissues, liver, and gastrointestinal tract. STARD10 is regulated by Casein kinase II, which phosphorylates STARD10 at serine 284 leading to decreased lipid transfer activity and reduced membrane association. STARD10 is overexpressed in breast carcinoma cell lines and in primary breast cancers (3). STARD10 has been implicated in the regulation of bile acid homeostasis and more recently in the regulation of insulin secretion from beta-cells (1, 2, 4).

References

1. Alpy, F., & Tomasetto, C. (2005). Give lipids a START: The StAR-related lipid transfer (START) domain in mammals. Journal of Cell Science. https://doi.org/10.1242/jcs.02485

2. Alpy, F., Legueux, F., Tomasetto, C., & Bianchetti, L. (2009). START domain-containing proteins: A review of their role in lipid transport and exchange. Medecine/Sciences. https://doi.org/10.1051/medsci/2009252181

3. Olayioye, M. A., Hoffmann, P., Pomorski, T., Armes, J., Simpson, R. J., Kemp, B. E.,... Visvader, J. E. (2004). The phosphoprotein StarD10 is overexpressed in breast cancer and cooperates with ErbB receptors in cellular transformation. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-03-3731

4. Carrat, G. R., Hu, M., Nguyen-Tu, M. S., Chabosseau, P., Gaulton, K. J., van de Bunt, M.,... Rutter, G. A. (2017). Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice. American Journal of Human Genetics. https://doi.org/10.1016/j.ajhg.2017.01.011

Bioinformatics

Entrez Human
Uniprot Human
Human
Product By Gene ID 10809
Alternate Names
  • StARD10
  • StAR-related lipid transfer protein 10
  • PCTP-like protein
  • Antigen NY-CO-28
  • MGC14401
  • START domain containing 10
  • CGI-52
  • PCTP2
  • START domain-containing protein 10
  • NY-CO-28
  • Serologically defined colon cancer antigen 28SDCCAG28
  • PCTP-L
  • StAR-related lipid transfer (START) domain containing 10

Pathways for STARD10

View related products by pathway and learn more about each of the pathways below.

Transport
Lipid Binding
Lipid Transport
Localization
Excretion
Epithelial To Mesenchymal Transition
Cell-cell Adhesion
Secretion
Oncogenesis

PTMs for STARD10

Learn more about PTMs related to STARD10.

Phosphorylation

Bioinformatics Tool for STARD10

Discover related pathways, diseases and genes to STARD10. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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