Smad2 Products

Antibodies
Smad2 Antibody
Smad2 Antibody
NB100-56462
Species: Hu, Mu, Rt, Bv, Ca, Ch, Pm
Applications: WB, IHC-P
Host: Rabbit Polyclonal
Smad2 Antibody (5G7)
Smad2 Antibody (5G7)
NBP2-37580
Species: Hu
Applications: WB, ELISA, Flow, ICC/IF, IHC
Host: Mouse Monoclonal
Smad2 Antibody
Smad2 Antibody
AF7948
Species: Dr
Applications: WB, IHC
Host: Sheep Polyclonal
Lysates
Smad2 Overexpression Lysate ( ...
Smad2 Overexpression Lysate (Native)
NBL1-16221
Applications: WB
Smad2 Overexpression Lysate ( ...
Smad2 Overexpression Lysate (Native)
NBL1-16220
Applications: WB
Proteins
Smad2 Recombinant Protein
Smad2 Recombinant Protein
NBC1-25856
Species: Hu
Applications: PAGE
RNAi
Smad2 RNAi
Smad2 RNAi
H00004087-R01
Species: Hu
Applications: RNAi, RNAi SP
Smad2 RNAi
Smad2 RNAi
H00004087-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

Smad 2 is a member of the Mothers Against Dpp (MAD)-related family of proteins. So far, nine Smads have been identified and can be divided in 3 subgroups based on their structure and functions; pathway-restricted, common mediator and inhibitory Smad. Smad 2 and 3 serve as pathway-restricted Smads for the TGF-beta/activin signaling pathways (1-2). Smad 2 is phosphorylated by the TGF-beta type 1 receptor kinase on Ser 465 and Ser 467. Phosphorylation of both serines is essential for Smad 2-Smad4 heteromeric complex and dissociation of Smad 2 from the TGF-beta type 1 receptor (3). Once phosphorylated Smad2 translocate to the nucleus where it associates with DNA-binding proteins and forming a transcriptional complex (4). Unlike Smad 3 and 4, Smad 2 does not directly bind DNA (5).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 4087
Alternate Names
  • Smad2
  • JV18
  • SMAD, mothers against DPP homolog 2
  • SMAD 2
  • Sma- and Mad-related protein 2
  • Mad-related protein 2
  • mothers against decapentaplegic homolog 2
  • MAD homolog 2
  • mother against DPP homolog 2
  • hSMAD2
  • Mad, mothers against decapentaplegic homolog 2
  • hMAD-2
  • Mad protein homolog
  • Mothers against DPP homolog 2
  • MADH2MGC34440
  • MADR2MGC22139
  • JV18-1SMAD, mothers against DPP homolog 2 (Drosophila)
  • SMAD family member 2MAD, mothers against decapentaplegic homolog 2 (Drosophila)

Research Areas for Smad2

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Cycle and Replication
Phospho-Specific
Wnt Signaling Pathway

Bioinformatics Tool for Smad2

Discover related pathways, diseases and genes to Smad2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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