WB, ICC/IF, IHC-PHost:
Hu, Mu, Rt, GeApplications:
WB, Simple Western, IHC, IHC-Fr, IHC-P, IPHost:
Hu, Mu, RtApplications:
WB, ICC/IF, IPHost:
Applications: B/N, Ctrl
Smac/DIABLO is a mitochondrial protein which activates various forms of apoptosis. Specifically, Smac exits the mitochondria and enters the cytosol where it initiates apoptosis by neutralizing members of the IAP family of apoptosis inhibitory proteins. Mitochondrial-mediated apoptosis is important in animal development and tissue homeostasis, with alterations resulting in a range of malignant disorders. Upon apoptotic stimuli, the mitochondrial proteins cytochrome c and Smac/DIABLO are released into the cytosol. The release of these proteins, however, occurs via different mechanisms.
|Product By Gene ID
- Second mitochondria-derived activator of caspase
- mitochondrial Smac protein
- Direct IAP-binding protein with low pI
- diablo, IAP-binding mitochondrial protein
Bioinformatics Tool for SMAC/Diablo
Discover related pathways, diseases and genes to SMAC/Diablo. Need help? Read the Bioinformatics Tool Guide
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