SMAC/Diablo Products

Description

Smac/DIABLO is a mitochondrial protein which activates various forms of apoptosis. Specifically, Smac exits the mitochondria and enters the cytosol where it initiates apoptosis by neutralizing members of the IAP family of apoptosis inhibitory proteins. Mitochondrial-mediated apoptosis is important in animal development and tissue homeostasis, with alterations resulting in a range of malignant disorders. Upon apoptotic stimuli, the mitochondrial proteins cytochrome c and Smac/DIABLO are released into the cytosol. The release of these proteins, however, occurs via different mechanisms.

Bioinformatics

Entrez	288753 Rat 56616 Human 66593 Mouse
Uniprot	AAF87716 Human AAH11909 Human NP_063940 Human NP_063940.1 Human Q9NR28 Human
Product By Gene ID	56616
Alternate Names	0610041G12Rik diablo, IAP-binding mitochondrial protein Direct IAP-binding protein with low pI mitochondrial Smac protein Second mitochondria-derived activator of caspase Smac SMACmitochondrial

Research Areas for SMAC/Diablo

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Biology
Cellular Markers
Mitochondrial Markers
Tumor Suppressors

Related SMAC/Diablo Blog Posts

Check out the latest blog posts on SMAC/Diablo.

Apoptosis and Necroptosis Part II: Inhibitors of apoptosis proteins (IAPs); Key regulators of the balance between necroptosis, apoptosis and survival In the first installment of this two-part blog post titled "Apoptosis and Necroptosis: Important factors to identify both types of programmed cell death", the mechanisms by which cell death occurs and ways to identify these pathways were ...    Read more.

Read more SMAC/Diablo related blogs.