SMAC/Diablo Products

Antibodies
SMAC/Diablo Antibody
SMAC/Diablo Antibody
NB100-56311
Species: Hu
Applications: WB, ICC/IF, IHC-P
Host: Rabbit Polyclonal
SMAC/Diablo Antibody
SMAC/Diablo Antibody
NB100-56165
Species: Hu, Mu, Rt, Ge
Applications: WB, Simple Western, IHC, IHC-Fr, IHC-P, IP
Host: Rabbit Polyclonal
SMAC/Diablo Antibody (78-1-11 ...
SMAC/Diablo Antibody (78-1-118)
NB500-213
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IP
Host: Mouse Monoclonal
Lysates
SMAC/Diablo Overexpression Ly ...
SMAC/Diablo Overexpression Lysate ...
H00056616-T01
Species: Hu
Applications: WB
SMAC/Diablo Overexpression Ly ...
SMAC/Diablo Overexpression Lysate ...
NBP2-06695
Applications: WB
SMAC/Diablo Overexpression Ly ...
SMAC/Diablo Overexpression Lysate ...
NBP2-11272
Applications: WB
Proteins
SMAC/Diablo Recombinant Prote ...
SMAC/Diablo Recombinant Protein An...
NBP1-84262PEP
Species: Hu
Applications: AC
Recombinant Human SMAC/Diablo ...
Recombinant Human SMAC/Diablo Protein
NBC1-18509
Species: Hu
Applications: PAGE
SMAC/Diablo Blocking Peptide
SMAC/Diablo Blocking Peptide
NBP1-76772PEP
Species: Mu
Applications: AC
RNAi
SMAC/Diablo RNAi
SMAC/Diablo RNAi
H00056616-R01
Species: Hu
Applications: RNAi, RNAi SP
SMAC/Diablo RNAi
SMAC/Diablo RNAi
H00056616-R02
Species: Hu
Applications: RNAi, RNAi SP
SMAC/Diablo RNAi
SMAC/Diablo RNAi
H00056616-R03
Species: Hu
Applications: RNAi, RNAi SP

Description

Smac/DIABLO is a mitochondrial protein which activates various forms of apoptosis. Specifically, Smac exits the mitochondria and enters the cytosol where it initiates apoptosis by neutralizing members of the IAP family of apoptosis inhibitory proteins. Mitochondrial-mediated apoptosis is important in animal development and tissue homeostasis, with alterations resulting in a range of malignant disorders. Upon apoptotic stimuli, the mitochondrial proteins cytochrome c and Smac/DIABLO are released into the cytosol. The release of these proteins, however, occurs via different mechanisms.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 56616
Alternate Names
  • Smac
  • Second mitochondria-derived activator of caspase
  • mitochondrial Smac protein
  • Direct IAP-binding protein with low pI
  • SMACmitochondrial
  • 0610041G12Rik
  • diablo, IAP-binding mitochondrial protein

Research Areas for SMAC/Diablo

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Biology
Cellular Markers
Mitochondrial Markers
Tumor Suppressors

Bioinformatics Tool for SMAC/Diablo

Discover related pathways, diseases and genes to SMAC/Diablo. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related SMAC/Diablo Blog Posts

Check out the latest blog posts on SMAC/Diablo.
Apoptosis and Necroptosis Part II: Inhibitors of apoptosis proteins (IAPs); Key regulators of the balance between necroptosis, apoptosis and survival
In the first installment of this two-part blog post titled "Apoptosis and Necroptosis: Important factors to identify both types of programmed cell death", the mechanisms by which cell death occurs and ways to identify these pathways were...    Read more.
Read more SMAC/Diablo related blogs.