SHC1 Products

Antibodies
SHC1 Antibody (3F4)
SHC1 Antibody (3F4)
H00006464-M01
Species: Hu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P, PLA
Host: Mouse Monoclonal
SHC1 Antibody (3A1)
SHC1 Antibody (3A1)
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
SHC1 Antibody (725001)
SHC1 Antibody (725001)
MAB7129
Species: Hu, Mu, Rt
Applications: WB
Host: Mouse Monoclonal
Lysates
SHC1 Overexpression Lysate (N ...
SHC1 Overexpression Lysate (Native)
NBL1-15936
Applications: WB
Proteins
SHC1 Recombinant Protein Anti ...
SHC1 Recombinant Protein Antigen
NBP1-87361PEP
Species: Hu
Applications: AC
SHC1 Recombinant Protein
SHC1 Recombinant Protein
NBP1-72374
Species: Hu
Applications: PAGE
RNAi
SHC1 RNAi
SHC1 RNAi
H00006464-R02
Species: Hu
SHC1 RNAi
SHC1 RNAi
H00006464-R01
Species: Hu

Description

Signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc andisoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of theGRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoformp52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shcdoes not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular responseto oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and isindispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome crelease and apoptosis. The expression of isoform p66Shc has been correlated with life span

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 6464
Alternate Names
  • p66SHC
  • SHC-transforming protein 1
  • SH2 domain protein C1
  • SHCA
  • FLJ26504
  • SHC
  • p66
  • Src homology 2 domain-containing-transforming protein C1
  • SHC-transforming protein A
  • SHC (Src homology 2 domain-containing) transforming protein 1
  • SHC-transforming protein 3
  • SHC (Src homology 2 domain containing) transforming protein 1

Research Areas for SHC1

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Phospho-Specific
Signal Transduction

Bioinformatics Tool for SHC1

Discover related pathways, diseases and genes to SHC1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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