Species: Hu, Mu
Applications: WB, ICC/IF (-), IHC (-)
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
Species: Hu
Applications: AC
Description
SETD8 (KMT5A, SET8, PR-Set7, SET domain containing (lysine methyltransferase) 8) is a methyltransferase that appears to be involved in cell cycle regulation; primarily during G2/M phase. A recent study has shown that KMT5A is regulated by phosphorylation at Ser 29 by the cyclin-dependent kinase 1/cyclinB complex from prophase through early anaphase following accumulation of H4K20me1. While the phosphorylation did not alter KMT5A methyltransferase activity, it did cause the removal of KMT5A from mitotic chromosomes. This study also showed that dephosphorylation of Ser 29 in KMT5A during late mitosis is vital to proper mitotic progression. If Ser 29 is not dephosphorylated at the proper time, a delay between metaphase and anaphase occurs (PMID: 20966048). Another study showed that KMT5A binds to the H4 N-terminal tail, consequently blocking the acetylation of lysine residues K5, K8 and K12 of histone H4 during G1, which can inhibit DNA replication (PMID: 18418072).
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
|
| Product By Gene ID |
387893 |
| Alternate Names |
- H4-K20-HMTase KMT5A
- H4-K20-HMTase SETD8
- H4K20-specific histone methyltransferase splice variant Set8b
- Histone-lysine N-methyltransferase SETD8
- KMT5A SET domain-containing protein 8
- KMT5A
- Lysine N-methyltransferase 5A
- PR/SET domain containing protein 8
- PR/SET domain-containing protein 07
- PR/SET07
- PRSET7
- PR-Set7
- PR-Set7EC 2.1.1.43
- SET domain containing (lysine methyltransferase) 8
- SET07
- SET07SET8H4-K20-specific histone methyltransferase
- SET8
- SETD8
|
