SETD8 Products

Description

Histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4. H4 'Lys-20'monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression.Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNAduring mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substratecompared to free histones

Bioinformatics

Entrez	387893 Human
Uniprot	AAF97812 Human Q9NQR Human Q9NQR1 Human
Product By Gene ID	387893
Alternate Names	H4-K20-HMTase SETD8 H4K20-specific histone methyltransferase splice variant Set8b Histone-lysine N-methyltransferase SETD8 KMT5A SET domain-containing protein 8 KMT5A Lysine N-methyltransferase 5A PR/SET domain containing protein 8 PR/SET domain-containing protein 07 PR/SET07 PRSET7 PR-Set7EC 2.1.1.43 SET domain containing (lysine methyltransferase) 8 SET07SET8H4-K20-specific histone methyltransferase SET8

Research Areas for SETD8

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Epigenetics