Psoriasin / S100A7 is encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. This protein is markedly over-expressed in the skin lesions of psoriatic patients, but is excluded as a candidate gene for familial psoriasis susceptibility. The exact function of this protein is not known.
![Immunohistochemistry S100A7/Psoriasin Antibody (577513) [Unconjugated]](http://images.novusbio.com/fullsize2/S100A7_MAB4475_Immunohistochemistry_10545.jpg)
![Bioactivity S100A7/Psoriasin [Unconjugated]](http://images.novusbio.com/fullsize2/S100A7_9085SA_1125.jpg)
