Rif1 Products

Description

Rif1 (Rap1-interacting factor homolog) is a protein whose primary function is in the DNA-damage response, RIF1 forms foci that colocalize with other DNA damage response factors, after induction of double-strand breaks. Rif1 localizes to double strand breaks in an ATM (ataxia telangiectasia mutated)- and 53BP1-dependent manner and functions in the intra-S-phase checkpoint that serves to slow down DNA synthesis when DNA damage has occurred.

Bioinformatics

Entrez	55183 Human 51869 Mouse 295602 Rat
Uniprot	NP_060621 Human NP_060621.3 Human Q5UIP0 Human Q6PR54 Mouse
Product By Gene ID	55183
Alternate Names	telomere-associated protein RIF1 DKFZp434D1026 FLJ10599 Rap1-interacting factor 1 homolog FLJ12870 DKFZp781N1478 RAP1 interacting factor homolog (yeast)

Diseases related to Rif1

Discover more about diseases related to Rif1.

Neoplasms
Neoplasms, Experimental
Hypoxia
Malignant Neoplasms
Malignant Neoplasm Of Breast
Sarcoma, Experimental
Fibrosarcoma
Carcinoma
Mammary Neoplasms
Sarcoma
Neoplasm Metastasis
Ataxia
Pathologic Neovascularization
Ataxia Telangiectasia
Anoxia

Pathways for Rif1

View related products by pathway and learn more about each of the pathways below.

Dna Replication
Cell Cycle
Localization
Cell Killing
Telomere Maintenance
Mating
Dna Replication Checkpoint
Cell Growth
Rna Interference
Interphase
Dna Repair
S Phase
Pathogenesis
Ribosome Assembly
Replicative Senescence
Translation
Meiosis
Telomere Capping
Senescence
Nitrogen Fixation

PTMs for Rif1

Learn more about PTMs related to Rif1.

Nitration
Acetylation
Phosphorylation
Farnesylation
Cleavage
Methylation
Acylation
Palmitoylation

Bioinformatics Tool for Rif1

Discover related pathways, diseases and genes to Rif1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 

Related Rif1 Blog Posts

Check out the latest blog posts on Rif1.

The recent relationship of BRCA1 and 53BP1 The p53-binding protein 1 (53BP1) is a DNA damage response factor, which is recruited to nuclear structures at the site of DNA damage.  DNA double-strand breaks (DSBs) are mutations that are detrimental to cell viability and genome stability, and m...    Read more.

Read more Rif1 related blogs.