RELM beta Products

Description

RELM beta is a family of resistin-like molecules (RELMs) has been identified in rodents and humans. Resistin is a hormone produced by fat cells. RELMalpha is a secreted protein that has a restricted tissue distribution with highest levels in adipose tissue. Another family member, RELMbeta, is a secreted protein expressed only in the gastrointestinal tract, particularly the colon, in both mouse and human. RELMbeta gene expression is highest in proliferative epithelial cells and is markedly increased in tumors, suggesting a role in intestinal proliferation. Resistin and the RELMs share a cysteine composition and other signature features. Thus, the RELMs together with resistin comprise a class of tissue-specific signaling molecules. mRELM-alpha should migrate as a monomer under complete reducing conditions. However, it migrates as dimers, trimers, and even higher order multimers under non-reducing conditions.

Bioinformatics

Entrez	57262 Mouse 57263 Mouse 84666 Human
Uniprot	NM_032579 Human NP_115968 Human NP_115968.1 Human Q2UXL7 Human Q9BQ08 Human
Product By Gene ID	84666
Alternate Names	C/EBP-epsilon regulated myeloid-specific secreted cysteine-rich proteinprecursor 2 CCRG Colon and small intestine-specific cysteine-rich protein Colon carcinoma-related gene protein cysteine-rich secreted A12-alpha-like protein 1 Cysteine-rich secreted protein A12-alpha-like 1 Cysteine-rich secreted protein FIZZ2 FIZZ1 FIZZ2RELM-beta found in inflammatory zone 1 HXCP2XCP2 RELMb RELMbeta resistin like beta resistin-like beta RETNL2

Research Areas for RELM beta

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Cancer