Pyruvate Dehydrogenase E1-alpha subunit Products

Antibodies
Pyruvate Dehydrogenase E1-alp ...
Pyruvate Dehydrogenase E1-alpha su...
H00005160-B01P
Species: Hu
Applications: WB, ELISA, IHC, IHC-P
Host: Mouse Polyclonal
Pyruvate Dehydrogenase E1-alp ...
Pyruvate Dehydrogenase E1-alpha su...
H00005160-B03P
Species: Hu
Applications: WB, ELISA
Host: Mouse Polyclonal
Lysates
Pyruvate Dehydrogenase E1-alp ...
Pyruvate Dehydrogenase E1-alpha su...
H00005160-T01
Species: Hu
Applications: WB
Pyruvate Dehydrogenase E1-alp ...
Pyruvate Dehydrogenase E1-alpha su...
NBL1-14241
Applications: WB
Proteins
Pyruvate Dehydrogenase E1-alp ...
Pyruvate Dehydrogenase E1-alpha su...
H00005160-P01
Species: Hu
Applications: WB, ELISA, PA

Description

Pyruvate Dehydrogenase E1-alpha subunit (PDHE1 alpha) is a member of the pyruvate dehydrogenase complex (PDC) and is a nuclear-encoded mitochondrial matrix multienzyme complex that provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle by catalyzing the irreversible conversion of pyruvate into acetyl-CoA. The PDH complex is composed of multiple copies of 3 enzymes: E1 (PDHA1 or PDHE1), dihydrolipoyl transacetylase (DLAT), and dihydrolipoyl dehydrogenase (DLD). The E1 enzyme is a heterotetramer of 2 alpha and 2 beta subunits. The E1-alpha subunit contains the E1 active site and plays a key role in the function of the PDH complex. Enhanced expression of pyruvate dehydrogenase kinase-1 (PDK-1) results in phosphorylation of PDHE1 alpha at Serine 293, which in turn produces nearly complete inhibition of the pyruvate dehydrogenase complex (PDC). A recent study shows that inhibition of PDC activity in cancer cells restores normoxic stablization of HIF-1 alpha by glycolytic metabolites.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Product By Gene ID 5160
Alternate Names
  • pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
  • EC 1.2.4.1
  • pyruvate dehydrogenase complex, E1-alpha polypeptide 1
  • PDHE1-A type I
  • PHE1APDHCE1A
  • PDHA
  • pyruvate dehydrogenase (lipoamide) alpha 1

Research Areas for Pyruvate Dehydrogenase E1-alpha subunit

Find related products by research area and learn more about each of the different research areas below.

Cancer
Core ESC-Like Genes
Lipid and Metabolism
Phospho-Specific
Signal Transduction
Stem Cell Markers

PTMs for Pyruvate Dehydrogenase E1-alpha subunit

Learn more about PTMs related to Pyruvate Dehydrogenase E1-alpha subunit.

Decarboxylation
Phosphorylation
Demethylation
Methylation
Dephosphorylation
Oxidation
Ubiquitination

Bioinformatics Tool for Pyruvate Dehydrogenase E1-alpha subunit

Discover related pathways, diseases and genes to Pyruvate Dehydrogenase E1-alpha subunit. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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