Pyruvate Dehydrogenase E1-alpha subunit Products

Description

Pyruvate Dehydrogenase E1-alpha subunit (PDHE1 alpha) is a member of the pyruvate dehydrogenase complex (PDC) and is a nuclear-encoded mitochondrial matrix multienzyme complex that provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle by catalyzing the irreversible conversion of pyruvate into acetyl-CoA. The PDH complex is composed of multiple copies of 3 enzymes: E1 (PDHA1 or PDHE1), dihydrolipoyl transacetylase (DLAT), and dihydrolipoyl dehydrogenase (DLD). The E1 enzyme is a heterotetramer of 2 alpha and 2 beta subunits. The E1-alpha subunit contains the E1 active site and plays a key role in the function of the PDH complex. Enhanced expression of pyruvate dehydrogenase kinase-1 (PDK-1) results in phosphorylation of PDHE1 alpha at Serine 293, which in turn produces nearly complete inhibition of the pyruvate dehydrogenase complex (PDC). A recent study shows that inhibition of PDC activity in cancer cells restores normoxic stablization of HIF-1 alpha by glycolytic metabolites.

Bioinformatics

Entrez	5160 Human
Uniprot	AAH02406 Human NM_000284 Human NP_000275.1 Human P08559 Human
Product By Gene ID	5160
Alternate Names	EC 1.2.4.1 PDHA PDHE1-A type I PHE1APDHCE1A pyruvate dehydrogenase (lipoamide) alpha 1 pyruvate dehydrogenase complex, E1-alpha polypeptide 1 pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

Research Areas for Pyruvate Dehydrogenase E1-alpha subunit

Find related products by research area and learn more about each of the different research areas below.

Cancer
Core ESC-Like Genes
Lipid and Metabolism
Phospho-Specific
Signal Transduction
Stem Cell Markers

Related Pyruvate Dehydrogenase E1-alpha subunit Blog Posts

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Pyruvate Dehydrogenase E1-alpha subunit: Understanding the Catalysts in Glycolysis Pyruvate Dehydrogenase E1-alpha subunit (PDHA1) is one of multiple enzymes in a mitochondrial complex, called the Pyruvate Dehydrogenase (PDH) complex, involved in the transition between glycolysis and the tricarboxylic acid (TCA) cycle during...    Read more.

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