PITX2 Products

Description

Chimera RNA interference (chimera RNAi) is process by which small interfering RNA/DNA chimera triggers the destruction of mRNA for the original gene.  The discovery work, design, and application of chimera RNAi has been pioneered by Professor Kaoru Saigo and Dr. Kumiko Ui-Tei at the University of Tokyo.  Chimera RNAi has many advantages over the conventional siRNAs.  First, it has been demonstrated to have reliable knock-down for over 10,000 human genes.  Because the human genome is composed of an intricate, genetic network, chimera RNAi's unique design has successfully obviated the off-target effects including microRNA-based influence.  Another advantage of the chimera RNAi technology is its effectiveness at low concentrations (0.5nM to 5nM); only mRNA is destroyed so genomic genes are not affected.  Finally, having both the sense and anti-sense strands consisting RNA/DNA chimera, it offers much greater compound stability for streamlining in vitro and in vivo assays and applications while minimizing interferon induction and other adverse reactions.

Bioinformatics

Product By Gene ID

5308

Alternate Names

all1-responsive gene 1 ALL1-responsive protein ARP1 ARP1MGC20144 Brx1 Homeobox protein PITX2 IDG2 IGDS IGDS2 IHG2 IRID2 Otlx2 paired-like homeodomain 2 Paired-like homeodomain transcription factor 2MGC111022 pituitary homeo box 2 pituitary homeobox 2 PITX2 PTX2 RGS RGSRIEG1Brx1 rieg bicoid-related homeobox transcription factor 1 RIEG bicoid-related homeobox transcription factor RIEG RIEG1 RP1 RS Solurshin

Research Areas for PITX2

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