PITX2 Antibody [Janelia Fluor® 525]

• Reactivity: Hu
• Applications: IHC
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Janelia Fluor 525

PITX2 Antibody [Janelia Fluor® 525] Summary

• Immunogen: E. coli-derived recombinant human PITX2
  Ala149-Val317
  Accession # Q99697
• Specificity: Detects human PITX2 in direct ELISAs. In direct ELISAs, less than 5% cross-reactivity with recombinant human PITX1 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Gene: PITX2
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for PITX2 Antibody [Janelia Fluor® 525]

• all1-responsive gene 1
• ALL1-responsive protein ARP1
• ARP1MGC20144
• Brx1
• Homeobox protein PITX2
• IDG2
• IGDS
• IGDS2
• IHG2
• IRID2
• Otlx2
• paired-like homeodomain 2
• Paired-like homeodomain transcription factor 2MGC111022
• pituitary homeo box 2
• pituitary homeobox 2
• PITX2
• PTX2
• RGS
• RGSRIEG1Brx1
• rieg bicoid-related homeobox transcription factor 1
• RIEG bicoid-related homeobox transcription factor
• RIEG
• RIEG1
• RP1
• RS
• Solurshin

Background

PITX2 encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PITX2