PDE8A Products

Antibodies
PDE8A Antibody
PDE8A Antibody
NBP1-83160
Species: Hu
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
PDE8A Antibody
PDE8A Antibody
NBP1-52651
Species: Hu
Applications: WB, IP
Host: Rabbit Polyclonal
PDE8A Antibody
PDE8A Antibody
NB300-643
Species: Hu, Mu, Rt
Applications: WB, IP
Host: Rabbit Polyclonal
Lysates
PDE8A Overexpression Lysate ( ...
PDE8A Overexpression Lysate (Native)
NBL1-14232
Applications: WB
PDE8A Overexpression Lysate ( ...
PDE8A Overexpression Lysate (Denat...
H00005151-T01
Applications: WB
Proteins
PDE8A Partial Recombinant Pro ...
PDE8A Partial Recombinant Protein
H00005151-Q01
Species: Hu
Applications: WB, ELISA, PA
PDE8A Recombinant Protein
PDE8A Recombinant Protein
H00005151-P01
Species: Hu
Applications: WB, ELISA, PA
PDE8A Recombinant Protein Ant ...
PDE8A Recombinant Protein Antigen
NBP1-83160PEP
Species: Hu
Applications: AC
RNAi
PDE8A RNAi
PDE8A RNAi
H00005151-R04
Species: Hu
PDE8A RNAi
PDE8A RNAi
H00005151-R01
Species: Hu
PDE8A RNAi
PDE8A RNAi
H00005151-R02
Species: Hu

Description

Phosphodiesterase type 8 (PDE8) is one of the many phosphodiesterases that compartmentalize and hydrolyze cAMP into AMP. The cAMP-specific PDE8 family is comprised of 2 genes (PDE8A and PDE8B) each with multiple splice variants generated by RNA splicing and use of alternate initiation sites. PDE8 family is a high affinity cAMP-specific, IBMX sensitive PDE. PDE8 has a significant conserved region of about 270 amino acids common to all PDEs at the carboxy terminal apparently serves as the catalytic domain. The amino-terminal region of this protein is divergent and presumably accounts for the distinctive and regulatory properties unique to the individual PDE families. PDE8A protein showed significant homology to other cAMP-dependent PDEs (23%) within the catalytic domain. PDE8A is widely expressed in various tissues in contrast to PDE8B that is exclusively expressed in thyroid gland. The PDE8A transcripts are found in brain, pancreas, placenta, thyroid, spleen, trachea, prostate, and uterus.

Bioinformatics

Uniprot Human
Human
Human
Human
Product By Gene ID 5151
Alternate Names
  • high-affinity cAMP-specific and IBMX-insensitive 3'-5'-cyclic phosphodiesterase8A
  • FLJ16150
  • high affinity cAMP-specific and IBMX-insensitive 3'-5'-cyclic phosphodiesterase8A
  • EC 3.1.4.17
  • cAMP-specific cyclic nucleotide phosphodiesterase 8A
  • HsT19550
  • phosphodiesterase 8A

Research Areas for PDE8A

Find related products by research area and learn more about each of the different research areas below.

Lipid and Metabolism
Signal Transduction

PTMs for PDE8A

Learn more about PTMs related to PDE8A.

Phosphorylation
Deamination
Cleavage

Bioinformatics Tool for PDE8A

Discover related pathways, diseases and genes to PDE8A. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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