PBK Products

Description

A novel mitotic kinase, PDZ-binding kinase or PBK, which is upregulated in a variety of neoplasms including hematological malignancies, has been the focus of attention with a goal to understand its role in malignant conversion and to examine as a possible new therapeutic target in disparate types of cancer. Studies provide a plausible explanation for the role of PBK augmenting tumor cell growth following transient appearance in different types of progenitor cells in vivo (1). PBK is a newly identified member of a novel MEK3/6-related MAPKK that may be enrolled in the activation of lymphoid cells and support testicular functions (2). In vitro, PBK binds specifically to PDZ2 of hDlg through its C-terminal T/SXV motif. PBK and hDlg are phosphorylated at mitosis in HeLa cells, and the mitotic phosphorylation of PBK is required for its kinase activity. In vitro, cdc2/cyclin B phosphorylates PBK. This evidence shows how PBK could link hDlg or other PDZ-containing proteins to signal transduction pathways regulating the cell cycle or cellular proliferation (3).

Bioinformatics

Entrez	55872 Human
Uniprot	Q96KB5 Human
Product By Gene ID	55872
Alternate Names	Cancer/testis antigen 84 CT84MAPKK-like protein kinase EC 2.7.12.2 FLJ14385 Nori-3PDZ-binding kinase PDZ binding kinase serine/threonine protein kinase Spermatogenesis-related protein kinase SPKT-LAK cell-originated protein kinase TOPKlymphokine-activated killer T-cell-originated protein kinase

Research Areas for PBK

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication