PARC Products

Antibodies
PARC Antibody
PARC Antibody
NBP1-77222
Species: Hu, Mu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P, ICC, IF
Host: Rabbit Polyclonal
PARC Antibody
PARC Antibody
NB200-187
Species: Hu
Applications: WB, IP
Host: Rabbit Polyclonal
PARC Antibody
PARC Antibody
NB100-2300
Species: Hu
Applications: WB, IP
Host: Rabbit Polyclonal
Lysates
PARC Overexpression Lysate (N ...
PARC Overexpression Lysate (Native)
NBP2-10299
Applications: WB
Proteins
Recombinant Human PARC Protei ...
Recombinant Human PARC Protein
H00023113-Q01
Species: Hu
Applications: WB, ELISA, PA
PARC Recombinant Protein Anti ...
PARC Recombinant Protein Antigen
NBP2-58049PEP
Species: Hu
Applications: AC
PARC Recombinant Protein Anti ...
PARC Recombinant Protein Antigen
NBP1-92243PEP
Species: Hu
Applications: AC
RNAi
PARC RNAi
PARC RNAi
H00023113-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

PARC is a cytoplasmic anchor protein in p53 associated protein complexes. PARC directly interacted and formed an approximately 1MD complex with p53 in the cytoplasm of unstressed cells. In the absence of stress, inactivation of PARC induced nuclear localization of endogenous p53 and activated p53 dependent apoptosis. Overexpression of PARC promoted cytoplasmic sequestration of ectopic p53. Furthermore, abnormal cytoplasmic localization of p53 was observed in a number of neuroblastoma cell lines; RNA interference-mediated reduction of endogenous PARC significantly sensitized these neuroblastoma cells in the DNA damage response. These results revealed that PARC is a critical regulator in controlling p53 subcellular localization and subsequent function.

Bioinformatics

Uniprot Human
Human
Product By Gene ID 23113
Alternate Names
  • UbcH7-associated protein 1
  • parkin-like cytoplasmic p53 binding protein
  • p53-associated parkin-like cytoplasmic protein
  • cullin-9
  • CUL-9
  • RP3-330M21.2
  • PARCKIAA0708
  • H7AP1DKFZp686P2024
  • DKFZp686G1042
  • cullin 9

Diseases related to PARC

Discover more about diseases related to PARC.

Leukemogenesis
Neoplasm Metastasis
Neoplasms
Lymphoma
Sarcoma
Carcinogenesis

Research Areas for PARC

Find related products by research area and learn more about each of the different research areas below.

Cancer
DNA Repair
Tumor Suppressors

Bioinformatics Tool for PARC

Discover related pathways, diseases and genes to PARC. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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