PARC Products

Description

PARC is a cytoplasmic anchor protein in p53 associated protein complexes. PARC directly interacted and formed an approximately 1MD complex with p53 in the cytoplasm of unstressed cells. In the absence of stress, inactivation of PARC induced nuclear localization of endogenous p53 and activated p53 dependent apoptosis. Overexpression of PARC promoted cytoplasmic sequestration of ectopic p53. Furthermore, abnormal cytoplasmic localization of p53 was observed in a number of neuroblastoma cell lines; RNA interference-mediated reduction of endogenous PARC significantly sensitized these neuroblastoma cells in the DNA damage response. These results revealed that PARC is a critical regulator in controlling p53 subcellular localization and subsequent function.

Bioinformatics

Uniprot	NP_055904 Human Q8IWT3 Human
Product By Gene ID	23113
Alternate Names	CUL-9 cullin 9 cullin-9 DKFZp686G1042 H7AP1DKFZp686P2024 p53-associated parkin-like cytoplasmic protein PARCKIAA0708 parkin-like cytoplasmic p53 binding protein RP3-330M21.2 UbcH7-associated protein 1

Research Areas for PARC

Find related products by research area and learn more about each of the different research areas below.

Cancer
DNA Repair
Tumor Suppressors