Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IP
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt, Bv, Ca, Do, Ha, Pm
Applications: WB, ELISA, ICC/IF
Host: Mouse Monoclonal
Species: Hu
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Description
NPM/B23 (also known as numatrin, nucleophosmin 1, nucleolar phosphoprotein B23) is a member of the nucleophosmin/nucleoplasmin family that shuttles between the nucleus and cytoplasm. This protein regulates the stability and transcriptional activity of p53 and acts as a molecular chaperone. NPM/B23 preferentially binds to denatured proteins and has been shown to stimulate DNA polymerase activity and control the duplication of centrosomes. The chaperone activity of NPM/B23 is regulated by protein kinase CK2 and promotes release of denatured substrates from NPM/B23. NPM/B23 is modified by phosphorylation onThr199. This protein has been shown to bind to RNA and DNA and interact with nucleolar proteins including nucleolin, protein P120, HIV-1 Rev protein, and hepatitis delta antigens. The Poly6192 antibody recognizes human phosphorylated NPM/B23 (Thr199) and has been shown to be useful for Western blotting.
Bioinformatics
| Entrez |
Human
|
| Product By Gene ID |
4869 |
| Alternate Names |
- B23
- MGC104254
- NPM1
- NPMnucleophosmin/nucleoplasmin family, member 1
- Nucleolar phosphoprotein B23
- Nucleolar protein NO38
- nucleophosmin (nucleolar phosphoprotein B23, numatrin)
- Nucleophosmin
- Numatrin
|
