Nephrin Products

Description

Nephrin is a member of the immunoglobulin family of cell adhesion molecules that localizes to opposing sites of the secondary foot processes formed by podocytes, a specialized epithelial cell that ensures size- and charge-selective ultrafiltration. The human nephrin gene maps to chromosome 19q13.1 and encodes a 1,241 amino acid protein that contains a transmembrane domain, 8 Ig-like modules, and 1 fibronectin III-like module. Nephrin is expressed in embryonic and adult kidneys and localizes to glomerular podocytes and the glomerular slit diaphragm. Nephrin stimulates mitogen-activated protein kinases and is enhanced by podocin, which binds to the cytoplasmic tail of nephrin. A293 cells treated with Phorbol-12-myristate- 13-acetate can upregulate nephrin, suggesting that protein kinase C is part of an intracellular signalling system, which regulates nephrin. Nephrin identified in mouse glomerular extract is a protein with an apparent molecular mass of 185 kDa.

Bioinformatics

Product By Gene ID	4868
Alternate Names	CNF Nephrin nephrosis 1, congenital, Finnish type (nephrin) NPHNCNF NPHS1 Renal glomerulus-specific cell adhesion receptor

Research Areas for Nephrin

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Phospho-Specific