MLF1 Interacting Protein Products

Description

Myeloid leukemia factor-1 (MLF1) Interacting Protein (also known as PBIP1, MLF1IP1, KLIP1 or KSHV latent nuclear antigen interacting protein 1) is a novel polo-like kinase 1 (Plk1) substrate. Plk1 phosphorylation of MLF1IP induces ubiquitination and degradation of MLF1IP prior to the metaphase/ anaphase transition. Several Plk1-dependent phosphorylation sites have been identified on MLF1IP by mass spectrometry. Mutations of these sites stabilize MLF1IP and inhibit mitotic progression. Subsequent in vitro and in vivo MLF1IP phosphorylation and stability assays have revealed that phosphorylation of Thr78 is critical for triggering Plk1-dependent MLF1IP degradation. Expression of a non-degradable Thr78Ala mutant was sufficient to induce a mitotic block. Timely phosphorylation of MLF1IP on Thr78 by Plk1 is critical for eliminating the MLF1IP-imposed mitotic block prior to anaphase onset. MLF1IP is speculated to be a novel tumor suppressor, whose function is required for proper sister-chromatid separation. Loss of MLF1IP function may result in improper segregation of chromosomes and genomic instability, thus promoting tumorigenesis.

Bioinformatics

Entrez	306464 Rat 71876 Mouse 79682 Human
Uniprot	AAH31520 Human NP_078905 Human Q71F23 Human
Product By Gene ID	79682
Alternate Names	CENP-50 CENP-U CENPU50 CENPUMLF1-interacting protein centromere protein of 50 kDa centromere protein U FLJ23468 ICEN24 Interphase centromere complex protein 24 KLIP1CENP50 KSHV latent nuclear antigen interacting protein 1 KSHV latent nuclear antigen-interacting protein 1 MLF1 interacting protein PBIP1 Polo-box-interacting protein 1

Research Areas for MLF1 Interacting Protein

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Phospho-Specific