MLF1 Interacting Protein Products

Antibodies
MLF1 Interacting Protein [p T ...
MLF1 Interacting Protein [p Thr78]...
NBP1-77938
Species: Hu, Bv, Ca, Pm
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
MLF1 Interacting Protein [p T ...
MLF1 Interacting Protein [p Thr78]...
NBP1-02440
Species: Hu, Mu, Rt, Bv, Ca, Pm
Applications: WB, ELISA, ICC/IF, IHC, IHC-P, IP
Host: Rabbit Polyclonal
MLF1 Interacting Protein Anti ...
MLF1 Interacting Protein Antibody
NBP1-85689
Species: Hu
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Proteins
MLF1 Interacting Protein Reco ...
MLF1 Interacting Protein Recombina...
NBP1-85689PEP
Species: Hu
Applications: AC
Recombinant Human MLF1 Intera ...
Recombinant Human MLF1 Interacting...
NBP2-23247
Species: Hu
Applications: PAGE

Description

Myeloid leukemia factor-1 (MLF1) Interacting Protein (also known as PBIP1, MLF1IP1, KLIP1 or KSHV latent nuclear antigen interacting protein 1) is a novel polo-like kinase 1 (Plk1) substrate. Plk1 phosphorylation of MLF1IP induces ubiquitination and degradation of MLF1IP prior to the metaphase/ anaphase transition. Several Plk1-dependent phosphorylation sites have been identified on MLF1IP by mass spectrometry. Mutations of these sites stabilize MLF1IP and inhibit mitotic progression. Subsequent in vitro and in vivo MLF1IP phosphorylation and stability assays have revealed that phosphorylation of Thr78 is critical for triggering Plk1-dependent MLF1IP degradation. Expression of a non-degradable Thr78Ala mutant was sufficient to induce a mitotic block. Timely phosphorylation of MLF1IP on Thr78 by Plk1 is critical for eliminating the MLF1IP-imposed mitotic block prior to anaphase onset. MLF1IP is speculated to be a novel tumor suppressor, whose function is required for proper sister-chromatid separation. Loss of MLF1IP function may result in improper segregation of chromosomes and genomic instability, thus promoting tumorigenesis.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Product By Gene ID 79682
Alternate Names
  • ICEN24
  • centromere protein of 50 kDa
  • KSHV latent nuclear antigen interacting protein 1
  • PBIP1
  • centromere protein U
  • Polo-box-interacting protein 1
  • Interphase centromere complex protein 24
  • FLJ23468
  • CENP-U
  • CENPU50
  • CENP-50
  • KLIP1CENP50
  • CENPUMLF1-interacting protein
  • KSHV latent nuclear antigen-interacting protein 1
  • MLF1 interacting protein

Pathways for MLF1 Interacting Protein

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Localization
Mitosis
Cell Cycle
Pathogenesis
Nuclear Export
Chromosome Segregation
Cytokinesis
Cell Maturation

Research Areas for MLF1 Interacting Protein

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Phospho-Specific

PTMs for MLF1 Interacting Protein

Learn more about PTMs related to MLF1 Interacting Protein.

Phosphorylation

Bioinformatics Tool for MLF1 Interacting Protein

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