MKK6/MEK6 Products

Description

Mitogen-acitvated protein kinase kinase 6 (MKK6) belongs to the serine/threonine protein kinase family and the MAPK kinase subfamily (MAP2K, MKK or MEKs). MAPKs require dual phosphorylation on threonine and tyrosine residues, an activation step carried out by MAPK kinase (1-2). MKK6, closely related to MKK3, efficiently phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines and environmental stress but not JNK or ERK (3). MTK1 phosphorylates MKK6 on serine 207 and threonine 211 (4).

Bioinformatics

Entrez	114495 Rat 26399 Mouse 5608 Human
Uniprot	AAH12009 Human NM_002758 Human NP_002749 Human NP_002749.2 Human P52564 Human
Product By Gene ID	5608
Alternate Names	MAP kinase kinase 6 MAPK/ERK kinase 6 MAPKK6dual specificity mitogen-activated protein kinase kinase 6 MEK6MAPKK 6 mitogen-activated protein kinase kinase 6 MKK6MEK 6 PRKMK6protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6) SAPKK3EC 2.7.12.2

Research Areas for MKK6/MEK6

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Apoptosis
Cancer
Cell Cycle and Replication
Hypoxia
Phospho-Specific
Protein Kinase