MGAT4B Products

Description

MGAT4B, also known as Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B, has 3 isoforms, a 548 amino acid isoform that is 63 kDa, a 547 amino acid isoform that is 63 kDa, and a 563 amino acid isoform that is 65 kDa; participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans; acts as a catalyzer in the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans; necessary for the production of tri- and tetra-antennary N-linked sugar chains, and it is not the main contributor in N-glycan biosynthesis. Disease research is currently being performed with relation to MGAT4B and immunodeficiency, pancreatic cancer, hepatocellular carcinoma, pancreatitis, interferon, carcinoma, and extrahepatic bile duct carcinoma. Interactions with this protein have been shown to involve LRSAM1, MGAT2, MGAT3, MGAT5, FUT8, and MGAT5B in N-glycan antennae elongation in the medial/trans-Golgi, transport to the Golgi and subsequent modification, asparagine N-linked glycosylation, N-Glycan antennae elongation, methabolism of proteins, N-Glycan biosynthesis, and metabolic pathways.

Bioinformatics

Entrez	11282 Human
Uniprot	NM_014275 Human NP_055090 Human NP_463459 Human NP_463459.1 Human
Product By Gene ID	11282
Alternate Names	alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B alpha-1,3-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase aminyltransferase EC 2.4.1.145 GlcNAc-T IVb GNT-IV GNT-IVB GnT-Ivb GnT-IVb isoenzyme B isozyme B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase N-acetylglucosaminyltransferase IVb N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb UDP-N-acetylglucosamine: alpha-1,3-D-mannosidebeta-1,4-N-acetylglucosaminyltransferase IV UDP-N-acetylglucosamine: alpha-1,3-D-mannosidebeta-1,4-N-acetylglucosaminyltransferase IVb

Research Areas for MGAT4B

Find related products by research area and learn more about each of the different research areas below.

Cytokine Research