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Description

Gene ID: 64135 DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon (IFNB) and a protein kinase C-activating compound, mezerein (MEZ). Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation.

Bioinformatics

Entrez	64135 Human
Uniprot	AAH46208.1 Human NM_022168 Human NP_071451 Human NP_071451. Human NP_071451.2 Human Q9BYX4 Human
Product By Gene ID	64135
Alternate Names	CADM-140 autoantigen Clinically amyopathic dermatomyositis autoantigen 140 kDa DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide EC 3.6.4.13 Helicard helicard Helicase with 2 CARD domains Hlcd IDDM19 interferon induced with helicase C domain 1 interferon-induced helicase C domain-containing protein 1 Interferon-induced with helicase C domain protein 1 MDA-5MGC133047 MDA5RNA helicase-DEAD box protein 116 melanoma differentiation associated protein-5 Melanoma differentiation-associated protein 5 Murabutide down-regulated protein RH116

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Cell Cycle and Replication

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