Livin Products

Antibodies
Livin Antibody
Livin Antibody
NB100-56145
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
Livin Antibody [Unconjugated] ...
Livin Antibody [Unconjugated]
AF1161
Species: Hu
Applications: WB, Simple Western
Host: Goat Polyclonal
Lysates
Livin Overexpression Lysate ( ...
Livin Overexpression Lysate (Denat...
H00079444-T01
Species: Hu
Applications: WB
Livin Overexpression Lysate ( ...
Livin Overexpression Lysate (Native)
NBL1-07988
Applications: WB
Livin Overexpression Lysate ( ...
Livin Overexpression Lysate (Native)
NBP2-06455
Applications: WB
Proteins
Livin Recombinant Protein
Livin Recombinant Protein
NBC1-18507
Species: Hu
Applications: PAGE
Livin Recombinant Protein
Livin Recombinant Protein
NBP1-99101
Species: Hu
Applications: PAGE
Livin Peptide
Livin Peptide
NBP1-76711PEP
Species: Hu
Applications: AC
RNAi
Livin RNAi
Livin RNAi
H00079444-R01
Species: Hu
Applications: RNAi, RNAi SP
Livin RNAi
Livin RNAi
H00079444-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

Livin (BIRC7/KIAP) is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain (reviewed in Ma et al 2006 and Crnkovic-Mertens et al 2006). Resistance towards apoptosis is a hallmark of cancer cells, and overexpression of IAPs can contribute to the development of cancer though inhibiting apoptosis (reviewed in Wright et al. 2005). IAP proteins inhibit apoptosis by binding to and inhibiting caspases through their BIR domain(s). Some IAP members, like Liven, also have a RING-type finger motif at their carboxyl-terminal which may enhance anti-apoptotic activity. Many RING finger-containing IAPs possess E3 ubiquitin ligase activity, and it has been shown that Liven acts an E3 ubiquitin ligase for targeting the degradation of Smac/DIABLO. Smac/DIABLO functions by inhibiting IAP-caspase interactions, thereby promoting apoptosis. Thus degradation of Smac/DIABLO is thought to be a mechanism to enhance Livin anti-apoptotic activity, thereby promoting cell survival. Two splicing variants of Livin, alpha and beta, have been identified. The two isoforms are thought to have different anti-apoptotic properties; however, there are conflicting reports are to whether they actually differ in their biological activities. There is accumulating evidence that Liven plays a significant role in a spectrum of tumor types and it is thought that Liven may have potential as a diagnostic and prognostic tumor marker. Liven is expressed at low levels in adult tissues, and relatively higher levels in developmental tissues and in many cancer cells. Certain cancer patients develop autoantibodies against liven and in a number of cancers, Liven is detected only in the tumors but not, or to substantially lower levels, in the corresponding normal adjacent tissue. This antibody recognizes Livin, both isoform alpha and isoform beta. Human Livin isoform alpha is a 298 amino acid (aa) protein, GenBank no. NP_647478. Human Livin isoform beta is a 280 aa protien, GenBank no. NP_071444.1. The antibody will also recognize other isoforms of Livin that contain the peptide immunogen sequence.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 79444
Alternate Names
  • Livin
  • Kidney inhibitor of apoptosis protein
  • livin inhibitor-of-apoptosis
  • baculoviral IAP repeat-containing 7
  • MLIAPlivin inhibitor of apoptosis
  • RNF50LIVINbaculoviral IAP repeat-containing protein 7
  • ML-IAPmliap
  • KIAPRING finger protein 50
  • Melanoma inhibitor of apoptosis protein
  • baculoviral IAP repeat containing 7

Research Areas for Livin

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Zinc Finger

PTMs for Livin

Learn more about PTMs related to Livin.

Cleavage
Ubiquitination
Phosphorylation

Bioinformatics Tool for Livin

Discover related pathways, diseases and genes to Livin. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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Related Livin Blog Posts

Check out the latest blog posts on Livin.
Survivin - an inhibitor of apoptosis protein
Survivin is an anti-apoptotic protein which is the smallest protein within a large family of proteins including X-linked IAP, c-IAP1 and 2, IAP-like protein-2, melanoma IAP, NAIP, and Livin. Survivin is responsible for a wide range of basic cellula...    Read more.
Survivin is thrivin'
The survivin anti-apoptotic protein is the smallest member of a large family of proteins such as X-linked IAP, c-IAP1 and 2, IAP-like protein-2, melanoma IAP, Livin, and NAIP. Survivin regulates basic physiological events such as the cell cycle, tumor...    Read more.
Livin: On a Prayer
Livin is a member of the inhibitor of apoptosis proteins (IAP) family that regulates programmed cell death. The Livin protein contains a single baculovirus IAP repeat (BIR) essential for function, along with a COOH-terminal RING-type zinc finger domai...    Read more.
Read more Livin related blogs.