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L-Selectin/CD62L Products

Antibodies
L-Selectin/CD62L Antibody [Un ...
L-Selectin/CD62L Antibody [Unconju...
AF728
Species: Hu
Applications: WB, B/N
Host: Sheep Polyclonal
Conjugate Catalog # Availability Size Price
Formulation Catalog # Availability Price  
L-Selectin/CD62L Antibody [Un ...
L-Selectin/CD62L Antibody [Unconju...
AF1534
Species: Rt
Applications: WB, IHC
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Formulation Catalog # Availability Price  
Antibody Pairs
L-Selectin/CD62L Antibody Pai ...
L-Selectin/CD62L Antibody Pair [HRP]
NBP2-79427
Species: Mu
Applications: ELISA
Host: Rabbit
Conjugate Catalog # Availability Size Price
L-Selectin/CD62L Antibody Pai ...
L-Selectin/CD62L Antibody Pair [HRP]
NBP2-79372
Species: Hu
Applications: ELISA
Host: Rabbit Monoclonal
Conjugate Catalog # Availability Size Price
ELISA Kits
Human L-Selectin/CD62L DuoSet ...
Human L-Selectin/CD62L DuoSet ELIS...
DY728
Species: Hu
Applications: ELISA
Mouse L-Selectin/CD62L DuoSet ...
Mouse L-Selectin/CD62L DuoSet ELIS...
DY576
Species: Mu
Applications: ELISA
Monkey L-Selectin/CD62L ELISA ...
Monkey L-Selectin/CD62L ELISA Kit ...
NBP2-76647
Species: Pm
Applications: ELISA
Lysates
L-Selectin/CD62L Overexpressi ...
L-Selectin/CD62L Overexpression Ly...
NBP2-10699
Species: Hu
Applications: WB
Proteins
Recombinant Human L-Selectin/ ...
Recombinant Human L-Selectin/CD62L...
728-LS
Species: Hu
Applications: Bioactivity
Formulation Catalog # Availability Price  
Recombinant Mouse L-Selectin/ ...
Recombinant Mouse L-Selectin/CD62L...
576-LS
Species: Mu
Applications: Bioactivity
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Recombinant Cyno/Rhesus L-Sel ...
Recombinant Cyno/Rhesus L-Selectin...
11192-LS
Species: Pm-Cm, RM
Formulation Catalog # Availability Price  

Description

L-selectin, also known as CD62L, is a type I transmembrane glycoprotein that is primarily expressed on leukocytes and has a role in cell adhesion and migration (1,2). L-selectin is closely related to the other family members E- and P-selectin (1,2). Human L-selectin protein is encoded by SELL and is 372 amino acids (aa) in length with a predicted molecular weight (MW) of ~30 kDa (1,2). However, due to glycosylation the observed MW ranges between 65-100 kDa and glycosylation is cell-type dependent (1,2). The L-selectin protein contains an N-terminal C-type lectin domain (CTLD), an epidermal growth factor (EGF)-like domain, two sequence consensus repeat (CSR) domains, a cleavage site, a transmembrane (TM) domain, and a short cytoplasmic tail (1,2).

L-selectin expressed on leukocytes binds to ligands expressed by endothelial cells where it plays a role in lymphocyte homing to secondary lymphoid organs (2-5). L-selectin specifically recognizes and binds to sulfated sialyl-Lewis epitopes of O-linked glycans (2-4). Ligands for L-selectin include glycosylation-dependent cell adhesion molecule-1 (GlyCAM-1), CD34, mucosal vascular addressin cell adhesion molecule-1 (MAdCAM-1), and P-selectin glycoprotein ligand-1 (PSGL-1) (2,4). Elevated levels of selectin ligands on tumor cells are associated with cancer progression and metastasis (3). High levels of L-selectin and soluble L-selectin (sL-selectin) has been implicated in a number of pathologies from viral infection and allergies, to sepsis and multiple sclerosis (2,4,5). For example, L-selectin has been shown to play a role in human immunodeficiency virus (HIV) infection. HIV envelope glycans, such as gp120, binds to L-selectin/CD62L on CD4+ T cells, facilitating viral adhesion (2,5). A disintegrin and metalloproteinase (ADAM)17 is the primary enzyme responsible for L-selectin shedding in leukocytes, which is triggered in response to inflammatory signals (1,2,5). AMAD17 inhibitors block L-selectin shedding and reduce viral release (2,5). Given their role in cancer and other diseases, selectins and their ligands are potential targets for therapeutic intervention (3,5). For instance, murine models have shown that anti-L-selectin antibodies can delay onset of graft versus host disease (5).

References

1. Ivetic A. (2018). A head-to-tail view of L-selectin and its impact on neutrophil behaviour. Cell and Tissue Research, 371(3), 437-453. https://doi.org/10.1007/s00441-017-2774-x

2. Ivetic, A., Hoskins Green, H. L., & Hart, S. J. (2019). L-selectin: a major regulator of leukocyte adhesion, migration and signaling. Frontiers in Immunology, 10, 1068. https://doi.org/10.3389/fimmu.2019.01068

3. Borsig L. (2018). Selectins in cancer immunity. Glycobiology, 28(9), 648-655. https://doi.org/10.1093/glycob/cwx105

4. Kneuer, C., Ehrhardt, C., Radomski, M. W., & Bakowsky, U. (2006). Selectins-potential pharmacological targets?. Drug Discovery Today, 11(21-22), 1034-1040. https://doi.org/10.1016/j.drudis.2006.09.004

5. Segura, J., He, B., Ireland, J., Zou, Z., Shen, T., Roth, G., & Sun, P. D. (2021). The role of L-Selectin in HIV infection. Frontiers in Microbiology, 12, 725741. https://doi.org/10.3389/fmicb.2021.725741

Bioinformatics

Entrez Mouse
Rat
Human
Uniprot Human
Human
Human
Mouse
Product By Gene ID 6402
Alternate Names
  • CD62L antigen
  • CD62L
  • gp90-MEL
  • hLHRc
  • LAM-1
  • LAM1LECAM1
  • LEU8
  • Leu-8
  • Leukocyte adhesion molecule 1
  • Leukocyte surface antigen Leu-8
  • Leukocyte-endothelial cell adhesion molecule 1
  • LNHRTQ1
  • LSEL
  • L-selectin
  • Lyam-1
  • LYAM1CD62 antigen-like family member L
  • Lymph node homing receptor
  • lymphocyte adhesion molecule 1
  • pln homing receptor
  • PLNHR
  • selectin L

Research Areas for L-Selectin/CD62L

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Immunology
Signal Transduction

Related L-Selectin/CD62L Blog Posts

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L-selectin (CD62L antigen, Leukocyte surface antigen Leu-8)
L-selectin is a member of the selectin family of glycoprotein adhesion and homing receptors that recognize sialyated carbohydrate groups and regulate lymphocyte-endothelial cell interactions. It is a type I transmembrane cell adhesion molecule (CAM) a...    Read more.
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