IL-24 Products

Description

This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Bioinformatics

Entrez	11009 Human
Uniprot	NP_006841 Human
Product By Gene ID	11009
Alternate Names	C49A FISP IL10B IL24 IL-24 interleukin 24 MDA-7 MDA7MOB5 melanocyte-associated Mda-7 melanoma differentiation association protein 7 Melanoma differentiation-associated gene 7 protein MOB-5 ST16 ST16interleukin-24 suppression of tumorigenicity 16 (melanoma differentiation) Suppression of tumorigenicity 16 protein

Research Areas for IL-24

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer