IDH3G Products

Description

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the gamma subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. This gene is a candidate gene for periventricular heterotopia. Several alternatively spliced transcript variants of this gene have been described, but only some of their full length natures have been determined. [provided by RefSeq]

Bioinformatics

Entrez	15929 Mouse 25179 Rat 3421 Human
Uniprot	AAH00933 Human NM_004135 Human NP_004126.1 Human NP_004126.1 Human NP_777358 Human NP_777358.1 Human P51553 Human
Product By Gene ID	3421
Alternate Names	EC 1.1.1 EC 1.1.1.41 H-IDHG IDH-gamma isocitrate dehydrogenase 3 (NAD+) gamma isocitrate dehydrogenase, NAD(+)-specific, mitochondrial, gamma subunit mitochondrial NAD (H)-specific isocitrate dehydrogenase gamma subunit NAD+-specific ICDH