HSP27 Products

Antibodies
HSP27 [p Ser82] Antibody (102 ...
HSP27 [p Ser82] Antibody (1026B) [...
MAB23141
Species: Hu
Applications: WB, ICC
Host: Rabbit Monoclonal
HSP27 Antibody [Unconjugated] ...
HSP27 Antibody [Unconjugated]
AF1580
Species: Hu, Mu
Applications: WB, Simple Western
Host: Rabbit Polyclonal
Antibody Pairs
HSP27 Antibody Pair
HSP27 Antibody Pair
H00003315-PW1
Species: Hu
Applications: WB, IP
ELISA Kits
HSP27 ELISA Kit [Biotin]
HSP27 ELISA Kit [Biotin]
KA0981
Species: Hu
HSP27 ELISA Kit [Biotin]
HSP27 ELISA Kit [Biotin]
KA1065
Species: Hu
HSP27 ELISA Kit [HRP]
HSP27 ELISA Kit [HRP]
KA1018
Species: Hu
Lysates
HSP27 Overexpression Lysate ( ...
HSP27 Overexpression Lysate (Native)
NBL1-11757
Applications: WB
HSP27 Overexpression Lysate ( ...
HSP27 Overexpression Lysate (Denat...
H00003315-T01
Applications: WB
Proteins
HSP27 Recombinant Protein
HSP27 Recombinant Protein
NBC1-18364
Species: Hu
Applications: PAGE
HSP27 Recombinant Protein Ant ...
HSP27 Recombinant Protein Antigen
NBP1-89666PEP
Species: Hu
Applications: AC
HSP27 Recombinant Protein
HSP27 Recombinant Protein
NBP1-30308
Species: Hu
Applications: PAGE
RNAi
HSP27 RNAi
HSP27 RNAi
H00003315-R01
Species: Hu

Description

Hsp25 is the mouse homologue of the human Hsp27 protein, a member of the small heat shock protein family comprised of a diverse group of proteins from approx. 15 to >30kDa(1). The basic structure of most sHsps is a homologous and highly conserved amino acid sequence, with an alpha-crystallin-domain at the C-terminus and the WD/EPF domain at the less conserved N-terminus. This N-terminus is essential for the development of high molecular oligomers (2, 3). Hsp27-oligomers consist of stable dimers formed by as many as 8-40 Hsp27 protein monomers (4). The oligomerization status is connected with the chaperone activity: aggregates of large oligomers have high chaperone activity, whereas dimers have no chaperone activity (5). HSP27 is localized to the cytoplasm of unstressed cells but can redistribute to the nucleus in response to stress, where it may function to stabilize DNA and/or the nuclear membrane. It can be rapidly phosphorylated in response to physiological stimuli relevant to the cell type examined. Thus, hsp27 has been suggested to be an important intermediate in second messenger mediated signaling pathways (6). Other functions include chaperone activity (as mentioned above), thermotolerance in vivo, inhibition of apoptosis, and signal transduction. Specifically, in vitro, it acts as an ATP-independent chaperone by inhibiting protein aggregation and by stabilizing partially denatured proteins, which ensures refolding of the HSP70 complex. Hsp27 is also involved in the apoptotic signaling pathway because it interferes with the activation of cytochrome c/Apaf-1/dATP complex, thereby inhibiting the activation of procaspase-9. It is also hypothesized that hsp27 may serve some role in cross-bridge formation between actin and myosin (7). And finally, Hsp27 is also thought to be involved in the process of cell differentiation. The up-regulation of Hsp27 correlates with the rate of phosphorylation and with an increase of large oligomers. It is possible that Hsp27 may play a crucial role in termination of growth (8).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Mouse
Product By Gene ID 3315
Alternate Names
  • 28 kDa heat shock protein
  • HspB1
  • Stress-responsive protein 27
  • heat shock protein beta-1
  • Heat shock 27 kDa protein
  • HS.76067
  • Estrogen-regulated 24 kDa protein
  • DKFZp586P1322
  • heat shock 27kD protein 1
  • HMN2B
  • Hsp25
  • HSP28CMT2F
  • HSP27HSP 27
  • SRP27
  • heat shock 27kDa protein 1

Research Areas for HSP27

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Biology
Cell Cycle and Replication
Golgi Apparatus Markers
Membrane Trafficking and Chaperones
Neuroscience
Phospho-Specific

Bioinformatics Tool for HSP27

Discover related pathways, diseases and genes to HSP27. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related HSP27 Blog Posts

Check out the latest blog posts on HSP27.
Caspase 8 - a key mediator of apoptosis
Programmed cell death via apoptosis is a key controlled physiological process instigated by the cell death receptor family, their ligands, and the caspase cysteine protease family. All caspases exist in a precursor form that contains a prodomain, a...    Read more.
FLICE, FLICE, baby
Cell death via apoptosis is a fundamental cellular function triggered by the cell death receptor family and their ligands which signal through downstream adaptor molecules and the caspase protease family. All caspases exist in a precursor form compose...    Read more.
Read more HSP27 related blogs.