HSP27 Products

Description

Hsp27 is an important heat shock protein found in normal and malignant human cells. The basic structure of most Hsps is a highly conserved amino acid sequence with an alpha-crystallin domain at the C-terminus and WD/EPF domain at the less conserved N-terminus. The N-terminus is essential for formation of high molecular weight oligomers. Hsp27 oligomers are formed by as many as 8-40 Hsp 27 monomers. The degree of oligomerization is associated with chaperon activity: large oligomers have high chaperon activity, whereas dimers have no chaperon activity. Hsp27 is localized in the cytoplasm of unstressed cells but can redistribute to the nucleus in response to stress where it may function to stabilize DNA and/or the nuclear membrane. Hsp27 is also involved in the apoptotic signaling pathway because it interferes with activation of cytochrome C / Apaf-1 / dATP complex, thereby inhibiting activation of procaspase-9.

Bioinformatics

Entrez	3315 Human
Product By Gene ID	3315
Alternate Names	28 kDa heat shock protein DKFZp586P1322 Estrogen-regulated 24 kDa protein Heat shock 27 kDa protein heat shock 27kD protein 1 heat shock 27kDa protein 1 heat shock protein beta-1 HMN2B HS.76067 HSP25 HSP27 HSP27HSP 27 HSP28CMT2F HSPB1 SRP27 Stress-responsive protein 27

Research Areas for HSP27

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Biology
Cell Cycle and Replication
Golgi Apparatus Markers
Membrane Trafficking and Chaperones
Neuroscience

Related HSP27 Blog Posts

Check out the latest blog posts on HSP27.

Caspase 8 - a key mediator of apoptosis Programmed cell death via apoptosis is a key controlled physiological process instigated by the cell death receptor family, their ligands, and the caspase cysteine protease family. All caspases exist in a precursor form that contains a prodomain, a...    Read more.

FLICE, FLICE, baby Cell death via apoptosis is a fundamental cellular function triggered by the cell death receptor family and their ligands which signal through downstream adaptor molecules and the caspase protease family. All caspases exist in a precursor form compose...    Read more.

Read more HSP27 related blogs.