HPRG Products

Antibodies
HPRG Antibody (227901)
HPRG Antibody (227901)
MAB1869
Species: Hu
Applications: WB
Host: Mouse Monoclonal
HPRG Antibody [Unconjugated]
HPRG Antibody [Unconjugated]
AF1905
Species: Mu
Applications: WB
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
HPRG Antibody (242425) [Uncon ...
HPRG Antibody (242425) [Unconjugated]
MAB1905
Species: Mu
Applications: WB
Host: Rat Monoclonal
Antibody Pairs
HPRG Antibody Pair
HPRG Antibody Pair
H00003273-PW1
Species: Hu
Applications: WB, IP
Lysates
HPRG Overexpression Lysate (D ...
HPRG Overexpression Lysate (Denatu...
H00003273-T01
Species: Hu
Applications: WB
HPRG Overexpression Lysate (N ...
HPRG Overexpression Lysate (Native)
NBL1-11707
Applications: WB
Proteins
HPRG Recombinant Protein
HPRG Recombinant Protein
H00003273-P01
Species: Hu
Applications: WB, ELISA, PA
HPRG Recombinant Protein Anti ...
HPRG Recombinant Protein Antigen
NBP2-33594PEP
Species: Hu
Applications: AC
HPRG Recombinant Protein Anti ...
HPRG Recombinant Protein Antigen
NBP2-33723PEP
Species: Hu
Applications: AC

Description

HRG, also known as Histidine-rich glycoprotein, is a 525 amino acid protein that is approx. 60 kDa, functions as plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions; acts as an adapter protein; mediates clearance of necrotic cells; inhibits the formation of insoluble immune complexes; ties plasminogen to the cell surface; binds T-cells and alters the cell morphology; modulates angiogenesis; inhibits endothelial cell motility; plays a role in the regulation of tumor angiogenesis and tumor immune surveillance; and normalizes tumor vessels and promotes antitumor immunity by polarizing tumor-associated macrophages. Studies on this protein have shown a relationship with thrombophilia, thrombophilia due to elevated hrg, thrombophilia due to hrg deficiency, protein c deficiency, myocardial infarction, acute myocardial infarction, corneal neovascularization, thrombosis, rheumatoid arthritis, hyperhomocysteinemia, arthritis, retinal vein occlusion, graft versus host disease, nephrotic syndrome, diabetes mellitus, cd3, twinning, retinitis, and hepatitis b. This protein has been shown to have interactions with C1QB, FGA, C1QA, FCGR1A, PLG, and THBS1 in the hemostasis, platelet degranulation, dissolution of fibrin clot, platelet activation, signaling and aggregation, and response to elevated platelet cytosolic Ca2+ pathways.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Human
Mouse
Product By Gene ID 3273
Alternate Names
  • DKFZp779H1622
  • Histidine-proline-rich glycoprotein
  • HPRGHRGP
  • histidine-rich glycoprotein

Bioinformatics Tool for HPRG

Discover related pathways, diseases and genes to HPRG. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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