GFR alpha-2/GDNF R alpha-2 Products

Description

Members of the glial cell line derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN), play key roles in the control of vertebrate neuron survival and differentiation. Physiological responses to NTN require the presence of a novel glycosylphosphadidylinositol linked protein NTNRa, which is a cell surface receptor for NTN. The cDNAs encoding NTNRa from human, rat, chicken, and mouse have been cloned recently. NTNRa was also termed GDNFRb, Ret ligand 2 (RETL2) or TGFb related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRa2 recently. GFRa2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFRa2, and the Ret PTK form a complex to transduce NTN signal and to mediate NTN function.

Bioinformatics

Entrez	14586 Mouse 25136 Rat 2675 Human
Uniprot	AAC52036 Human NM_001495 Human NP_001486 Human O00451 Human
Product By Gene ID	2675
Alternate Names	GDNF family receptor alpha 2 GDNF family receptor alpha-2 GDNF receptor alpha-2 GDNF receptor beta GDNFR-alpha-2 GDNFR-beta GDNFRBRET ligand 2 GFR-alpha 2 GFR-alpha-2 glial cell line derived neurotrophic factor receptor, beta Neurturin receptor alpha NRTNR-alpha NTNRA NTNR-alpha PI-linked cell-surface accessory protein RETL2TGF-beta-related neurotrophic factor receptor 2 TGF-beta related neurotrophic factor receptor 2 TRN receptor, GPI-anchored TRNR2NRTNR-ALPHA

Research Areas for GFR alpha-2/GDNF R alpha-2

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Cytokine Research
Immunology