GFR alpha-1/GDNF R alpha-1 Products

Description

Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRalpha, which is a cell surface receptor for GDNF (1,2). The cDNAs encoding GDNFRalpha from human, rat, chicken and mouse have been cloned recently (1-5). GDNFRalpha was also termed Ret ligand 1 (RETL1) or TGF-beta-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRalpha-1 recently (5-7). GFRalpha-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFRalpha and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.

Bioinformatics

Entrez	25454 Rat 2674 Human
Uniprot	NP_001138925 Human NP_005255 Human NP_005255.1 Human NP_665736 Human NP_665736.1 Human P56159 Human
Product By Gene ID	2674
Alternate Names	DKFZp313E1012 DKFZp686J0156 GDNF family receptor alpha 1 GDNF family receptor alpha-1 GDNF receptor alpha-1 GDNFRAGFR-ALPHA-1 GDNFR-alpha-1 GDNFRMGC23045 GFR-alpha-1 Glial cell line-derived neurotrophic factor receptor alpha GPI-linked anchor protein PI-linked cell-surface accessory protein RET ligand 1 RET1L RETL1FLJ10561 TGF-beta related neurotrophic factor receptor 1 TGF-beta-related neurotrophic factor receptor 1 TRNR1FLJ31546

Research Areas for GFR alpha-1/GDNF R alpha-1

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Neuroscience
Signal Transduction