GAP-43 Products

Description

GAP43 (Growth associated protein 43) is a crucial component for regenerative response in the nervous system. GAP-43 is normally produced by neurons during developmental growth and axonal regeneration, but it is also expressed in specific regions of the normal adult nervous system. The protein is present at high levels in neuronal growth cones during development and axonal regeneration.

Heterozygous GAP3 knockout mice with GAP-43 levels reduced by one-half display significant memory impairments in cued conditioning, or on tests of nociceptive or auditory perception. Differentiating neurons that do not express GAP-43 show mislocalization of the centrosome and mitotic spindles, particularly in neurogenic cell divisions. Therefore, the neuronal precursor pool in the cerebellum fails to grow resulting in a cerebellum that is significantly smaller than normal. Total GAP-43 deletion is lethal within days of birth, demonstrating that GAP-43 is critical for the proper development of the mammalian CNS.

Bioinformatics

Entrez	14432 Mouse 2596 Human 29423 Rat
Uniprot	AAH07936 Human AAH07936.1 Human NP_002036 Human NP_002036.1 Human P06837 Mouse P07936 Rat P17677 Human
Product By Gene ID	2596
Alternate Names	Axonal membrane protein GAP-43 B-50 calmodulin-binding protein P-57 growth associated protein 43 Growth-associated protein 43 nerve growth-related peptide GAP43 Neural phosphoprotein B-50 neuromodulin neuron growth-associated protein 43 PP46 pp46 protein F1

Research Areas for GAP-43

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cellular Markers
Growth and Development
Neuronal Cell Markers
Neuroscience
Phospho-Specific

Related GAP-43 Blog Posts

Check out the latest blog posts on GAP-43.

Synapsin I: Implicated in synaptic activity across a diverse range of studies Synapsins are a family of neuronal proteins that are most renowned for their activity in modulating the pre-synaptic terminal.  Synapsin’s behavior is regulated by protein kinases and phosphatases, which alter the way that synapsin’s i...    Read more.

Read more GAP-43 related blogs.