GAP-43 Products

Antibodies
GAP-43 Antibody
GAP-43 Antibody
NB300-143
Species: Hu, Mu, Rt, Po, Ca, Ch, Pm
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-P
Host: Rabbit Polyclonal
GAP-43 Antibody
GAP-43 Antibody
NBP1-41123
Species: Hu, Mu, Rt, Ca, Fe, Ha, Pm
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-P
Host: Sheep Polyclonal
Lysates
GAP-43 Overexpression Lysate ...
GAP-43 Overexpression Lysate (Dena...
H00002596-T01
Species: Hu
Applications: WB
GAP-43 Overexpression Lysate ...
GAP-43 Overexpression Lysate (Native)
NBP2-04214
Applications: WB
Proteins
GAP-43 Recombinant Protein
GAP-43 Recombinant Protein
H00002596-P01
Species: Hu
Applications: WB, ELISA, PA
GAP-43 Recombinant Protein
GAP-43 Recombinant Protein
NBP2-53033
Species: Hu
Applications: PAGE

Description

GAP43 (Growth associated protein 43) is a crucial component for regenerative response in the nervous system. GAP-43 is normally produced by neurons during developmental growth and axonal regeneration, but it is also expressed in specific regions of the normal adult nervous system. The protein is present at high levels in neuronal growth cones during development and axonal regeneration.

Heterozygous GAP3 knockout mice with GAP-43 levels reduced by one-half display significant memory impairments in cued conditioning, or on tests of nociceptive or auditory perception. Differentiating neurons that do not express GAP-43 show mislocalization of the centrosome and mitotic spindles, particularly in neurogenic cell divisions. Therefore, the neuronal precursor pool in the cerebellum fails to grow resulting in a cerebellum that is significantly smaller than normal. Total GAP-43 deletion is lethal within days of birth, demonstrating that GAP-43 is critical for the proper development of the mammalian CNS.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Mouse
Rat
Product By Gene ID 2596
Alternate Names
  • pp46
  • Neural phosphoprotein B-50
  • protein F1
  • Growth-associated protein 43
  • neuron growth-associated protein 43
  • Axonal membrane protein GAP-43
  • neuromodulin
  • PP46
  • nerve growth-related peptide GAP43
  • B-50
  • calmodulin-binding protein P-57
  • growth associated protein 43

Research Areas for GAP-43

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cellular Markers
Growth and Development
Neuronal Cell Markers
Neuroscience
Phospho-Specific

Bioinformatics Tool for GAP-43

Discover related pathways, diseases and genes to GAP-43. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related GAP-43 Blog Posts

Check out the latest blog posts on GAP-43.
Synapsin I: Implicated in synaptic activity across a diverse range of studies
Synapsins are a family of neuronal proteins that are most renowned for their activity in modulating the pre-synaptic terminal.  Synapsin’s behavior is regulated by protein kinases and phosphatases, which alter the way that synapsin’s i...    Read more.
Read more GAP-43 related blogs.