Applications: WB, IHC
Host: Goat Polyclonal
Host: Mouse Monoclonal
Applications: RNAi, RNAi SP
Galectins are a family of soluble beta-galactoside-binding animal lectins that modulate cell-to-cell adhesion and cell-to-extracellular matrix (ECM) interactions and play a role in tumor progression, pre-mRNA splicing and apoptosis. One member of this family, Galectin-4, also known as Gal-4, L36 or LGALS4 maps to human chromosome 19q13.13 and encodes a 36-37 kDa protein. The Galectin-4 protein is composed of 323 amino acids and contains two homologous carbohydrate recognition domains (CRD) and all amino acids typically conserved in the galectin family. Expression of Galectin-4 correlates with the malignant potential of human hepatocellular carcinoma (HCC) and is differentially regulated depending on cell-cell contact, serum growth factors, cell growth and cell differentiation status. Galectin-4 expression is detected in epithelial cells of the colon, rectum, intestine, and in HT29 and LS174T cell lines. Galectin-4 is underexpressed in colorectal cancer and is preferentially upregulated in cells prone to peritoneal dissemination.
|Product By Gene ID
- Lactose-binding lectin 4
- galectin 4
- Antigen NY-CO-27
- L-36 lactose-binding protein
- lectin, galactoside-binding, soluble, 4
Research Areas for Galectin-4
Find related products by research area and learn more about each of the different research areas below.Cancer
Bioinformatics Tool for Galectin-4
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