Galectin-4 Products

Description

Galectins are a family of soluble beta-galactoside-binding animal lectins that modulate cell-to-cell adhesion and cell-to-extracellular matrix (ECM) interactions and play a role in tumor progression, pre-mRNA splicing and apoptosis. One member of this family, Galectin-4, also known as Gal-4, L36 or LGALS4 maps to human chromosome 19q13.13 and encodes a 36-37 kDa protein. The Galectin-4 protein is composed of 323 amino acids and contains two homologous carbohydrate recognition domains (CRD) and all amino acids typically conserved in the galectin family. Expression of Galectin-4 correlates with the malignant potential of human hepatocellular carcinoma (HCC) and is differentially regulated depending on cell-cell contact, serum growth factors, cell growth and cell differentiation status. Galectin-4 expression is detected in epithelial cells of the colon, rectum, intestine, and in HT29 and LS174T cell lines. Galectin-4 is underexpressed in colorectal cancer and is preferentially upregulated in cells prone to peritoneal dissemination.

Bioinformatics

Entrez	3960 Human
Uniprot	NP_006140 Human P56470 Human
Product By Gene ID	3960
Alternate Names	Antigen NY-CO-27 GAL4 gal-4 Gal-4 galectin 4 galectin-4 L-36 lactose-binding protein L36LBP Lactose-binding lectin 4 lectin, galactoside-binding, soluble, 4

Research Areas for Galectin-4

Find related products by research area and learn more about each of the different research areas below.

Cancer