DGK-theta Products

Description

Diacylglycerol (DAG) is a fundamental lipid second messenger that is produced in the nucleus. The accumulation of DAG in the nucleus is important for the regulation of cell growth and differentiation. Diacylglycerol kinases (DGKs) convert DAG to phosphatidic acid, thereby terminating diacylglycerol signaling, which results in the reduction of protein kinase C activity and cell cycle progression of T lymphocytes. Diacylglycerol kinases are divided into five subtypes, Type I-Type V. DGK-theta is a Type V DGK, and localizes mainly to the nucleus of various cell lines, such as MDA-MB-453, MCF-7, PC12 and HeLa. Nuclear DGK-theta co-localizes with phosphatidylinositol 4,5-bisphosphate (PIP(2)). DGK-theta is the isoform responsive to alpha-Thrombin stimulation.

Bioinformatics

Entrez	1609 Human
Product By Gene ID	1609
Alternate Names	DAG kinase theta DAGK DAGK4EC 2.7.1.107 DAGK7 DGKQ DGKtheta DGK-theta diacylglycerol kinase theta diacylglycerol kinase, theta (110kD) diacylglycerol kinase, theta 110kDa Diglyceride kinase theta

Research Areas for DGK-theta

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Lipid and Metabolism