DC-SIGNR/CD299/CLEC4M Products

Description

This gene encodes a type II integral membrane protein that is 77% identical to CD209 antigen, a HIV gp120-binding protein. This protein, like CD209, efficiently binds both intercellular adhesion molecule 3 (ICAM3) and HIV-1 gp120, and enhances HIV-1 infection of T cells. This gene is mapped to 19p13.3, in a cluster with the CD209 and CD23/FCER2 genes. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.

Bioinformatics

Entrez	10332 Human
Uniprot	NP_055072
Product By Gene ID	10332
Alternate Names	CD209L CD209L1 CD209Ldendritic cell-specific ICAM-3-grabbing nonintegrin 2 CD299 antigenMGC129964 CD299 CLEC4M C-type lectin domain family 4, member M DC-SIGN2 DC-SIGN2CD209 antigen-like protein 1 DCSIGNR DC-SIGNR DC-SIGNRDC-SIGN-related protein DCSIGNRMGC47866 Dendritic cell-specific ICAM-3-grabbing non-integrin 2 HP10347 liver/lymph node-specific ICAM-3 grabbing non-integrin Liver/lymph node-specific ICAM-3-grabbing non-integrin LSIGN L-SIGN LSIGNC-type lectin domain family 4 member M mannose binding C-type lectin DC-SIGNR

Research Areas for DC-SIGNR/CD299/CLEC4M

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Signal Transduction