Cytokeratin 14 Products

Description

Keratins are cytoplasmic intermediate filament proteins expressed by epithelial cells. Cytokeratin 14 (CK-14) is a 50-kDa keratin expressed in abundance in human epidermal cells (1). During anagen, cell proliferation in the germinative matrix of the hair follicle gives rise to the fiber and inner root sheath. The transition from anagen to telogen is marked by downregulation of hair cortical specific keratins and the appearance of CK-14 in the epithelial sac to which the telogen hair fiber is anchored (2). A family with recessive epidermolysis bullosa simplex lacked expression of the basal cell keratin 14. The patients had severe generalized skin blistering that improved slightly with age. The basal cells of the patients did not express keratin 14 and contained no keratin intermediate filaments. The expression of keratin 5, the obligate copolymer of keratin 14, was slightly reduced (3).

Bioinformatics

Uniprot	P02533 Human
Product By Gene ID	3861
Alternate Names	CK14 CK-14 Cytokeratin 14 cytokeratin-14 EBS3 EBS4 K14 keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner) keratin 14 keratin, type I cytoskeletal 14 keratin-14 KRT14 NFJ

Research Areas for Cytokeratin 14

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Cell Biology
Cellular Markers