Connexin 43/GJA1 Products

Description

Chimera RNA interference (chimera RNAi) is process by which small interfering RNA/DNA chimera triggers the destruction of mRNA for the original gene. The discovery work, design, and application of chimera RNAi has been pioneered by Professor Kaoru Saigo and Dr. Kumiko Ui-Tei at the University of Tokyo. Chimera RNAi has many advantages over the conventional siRNAs. First, it has been demonstrated to have reliable knock-down for over 10,000 human genes. Because the human genome is composed of an intricate, genetic network, chimera RNAi's unique design has successfully obviated the off-target effects including microRNA-based influence. Another advantage of the chimera RNAi technology is its effectiveness at low concentrations (0.5nM to 5nM); only mRNA is destroyed so genomic genes are not affected. Finally, having both the sense and anti-sense strands consisting RNA/DNA chimera, it offers much greater compound stability for streamlining in vitro and in vivo assays and applications while minimizing interferon induction and other adverse reactions.

Bioinformatics

Product By Gene ID	2697
Alternate Names	Connexin 43 connexin-43 CX43 CX43gap junction protein, alpha-like DFNB38 Gap junction 43 kDa heart protein gap junction alpha-1 protein gap junction protein, alpha 1, 43kDa (connexin 43) gap junction protein, alpha 1, 43kDa GJA1 GJAL HSS ODD ODDD ODOD SDTY3

Research Areas for Connexin 43/GJA1

Find related products by research area and learn more about each of the different research areas below.

Cancer
Core ESC-Like Genes
Neuronal Cell Markers
Neuroscience
Signal Transduction
Stem Cell Markers

Related Connexin 43/GJA1 Blog Posts

Check out the latest blog posts on Connexin 43/GJA1.

Connexin: Bridging the Gap of Intercellular Communication Connexin 43/GJA1 is a member of the connexin gene family and the most abundant protein component found within gap junctions. Gap junctions are the cell-to-cell contacts that provide direct intercellular communication between cells by regulating back a...    Read more.

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