Connexin: Bridging the Gap of Intercellular Communication

Mon, 06/11/2012 - 09:03

Connexin 43/GJA1 is a member of the connexin gene family and the most abundant protein component found within gap junctions. Gap junctions are the cell-to-cell contacts that provide direct intercellular communication between cells by regulating back and forth diffusion of low molecular weight molecules. As such, they regulate quite an extensive range of key cellular processes. Connexin 43/GJA1 antibodies are important tools in wound healing studies, as connexin expression changes dramatically in the skin during different stages of wound healing (1, 2). Clinical trials exploiting connexins as the newest and latest promising target for skin wound healing are ongoing (3).  Connexin 43/GJA1 has far-reaching potential therapeutic uses in other tissue and cell types.

Immunocytochemistry/Immunofluorescence: Connexin 43/GJA1 Antibody

It is being evaluated as a CNS injury therapeutic in astrocytes, where Connexin 43/GJA1antibodies are used to monitor cellular responses and neuronal survival (4).  The field of cardiac biology has also been revolutionized by a greater understanding of cardiac myocyte survival and death due to tools such as Connexin 43/GJA1 antibodies. In particular, they have helped to implicate mitochondrial K/ATP channels and Connexin 43/GJA1 as critical regulators of cardiac pathology (5). Furthermore, a review of the roles and functions of Connexin 43/GJA1 in germ cell development and spermatogenesis highlights the use of Connexin 43/GJA1 antibodies to study connexins in gap junction channels within the Sertoli junctions at the blood-testis barrier, as well their role in modulating tight and adherens junction proteins (6).

  1. PMID: 16628254
  2. PMID: 22155211
  3. PMID: 21841715
  4. PMID: 20655909
  5. PMID: 20148667
  6. PMID: 21870337

Novus Biologicals offers Connexin 43/GJA1 reagents for your research needs including:


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