CD74 Products

CD74 Antibody
CD74 Antibody
Species: Hu, Mu, Rt, Pm
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Antibody Pairs
CD74 Antibody Pair
CD74 Antibody Pair
Species: Hu
Applications: WB, IP
CD74 Overexpression Lysate (N ...
CD74 Overexpression Lysate (Native)
Applications: WB
CD74 Overexpression Lysate (N ...
CD74 Overexpression Lysate (Native)
Applications: WB
CD74 Overexpression Lysate (D ...
CD74 Overexpression Lysate (Denatu...
Species: Hu
Applications: WB
Recombinant Mouse CD74 Protei ...
Recombinant Mouse CD74 Protein, CF
Species: Mu
Applications: BA
Recombinant Human CD74 Protei ...
Recombinant Human CD74 Protein, CF
Species: Hu
Applications: BA
CD74 Recombinant Protein Anti ...
CD74 Recombinant Protein Antigen
Species: Hu
Applications: AC


CD74, also known as the MHC class II associated invariant chain (Ii), is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is produced in molar excess over MHC class II and some of this is expressed by an unknown pathway on the cell surface independent of, or in association with, MHC class II molecules. The half life of CD74 on the cell surface is only 3 to 4 min after which it is internalized. It has been proposed that cell surface CD74 binds MHC class II molecules which have lost their antigenic peptide leading to internalization and reloading with antigenic peptide. The transport route of class II alpha/beta/Ii complexes is regulated selectively by two forms of CD74 (p33 and p35) which are generated by the use of alternative translation initiation sites. CD74 is expressed primarily by antigen presenting cells such as B lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages and monocytes together, with many epithelial cells. CD74 may exist in different isoforms ranging in size from 33 to 41 kDa, depending on genetic splicing.


Entrez Human
Uniprot Human
Product By Gene ID 972
Alternate Names
  • Ia antigen-associated invariant chain
  • II
  • CD74 antigen
  • Ii
  • HLA-DR-gamma
  • MHC HLA-DR gamma chain
  • p33
  • Ia-associated invariant chain
  • HLA-DR antigens-associated invariant chain
  • HLA class II histocompatibility antigen gamma chain
  • CD74 antigen (invariant polypeptide of major histocompatibility complex, classII antigen-associated)
  • DHLAGgamma chain of class II antigens
  • Ia-GAMMA
  • CD74 molecule, major histocompatibility complex, class II invariant chain

Research Areas for CD74

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PTMs for CD74

Learn more about PTMs related to CD74.


Bioinformatics Tool for CD74

Discover related pathways, diseases and genes to CD74. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Vizit™, under license from BioVista Inc.

Related CD74 Blog Posts

Check out the latest blog posts on CD74.
CD74 - a central player in antigen presentation by MHC class II
Cluster of differentiation 74 (CD74) is an important integral membrane protein that serves as a chaperone for MHC class II molecules. CD74, also known as the invariant chain or Ii, is needed for the proper folding and trafficking of MHC class II in...    Read more.
Read more CD74 related blogs.