CD74 Products

Description

CD74 is a type II transmembrane glycoprotein, also known as MHC Class II associated invariant chain, invariant chain, Ii, MHC class II chaperone, or MIF receptor. CD74 exists in 4 isoforms with the molecular sizes 33, 35, 41, and 43 kDa depending on genetic splicing. CD74 is primarily expressed on antigen presenting cells, including B cells, monocytes/macrophages, dendritic cells, and Langerhans cells. It is also expressed by activated T cells, activated endothelial and epithelial cells as well as the carcinomas of lung, renal, gastric and thymic origin. The primary function of CD74 is for intracellular sorting of the MHC class II molecules, regulation of loading exogenous peptides onto MHC class II. It is also involved in the modulation of B cell differentiation and positive selection of CD4+ T cells. It has been reported that CD74 binds MIF (macrophage migration inhibitory factory) and signaling through CD44 to regulate innate and adaptive immunity, and that the H. pylori infection is through urease B binding CD74 on gastric epithelial cells and inducing cell activation.

Bioinformatics

Product By Gene ID

972

Alternate Names

CD74 antigen (invariant polypeptide of major histocompatibility complex, classII antigen-associated) CD74 antigen CD74 molecule, major histocompatibility complex, class II invariant chain CD74 CLIP DHLAG DHLAGgamma chain of class II antigens HLA class II histocompatibility antigen gamma chain HLADG HLA-DR antigens-associated invariant chain HLA-DR-gamma Ia antigen-associated invariant chain Ia-associated invariant chain Ia-gamma Ii INVG34 MHC HLA-DR gamma chain p33

Research Areas for CD74

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Immunology

Related CD74 Blog Posts

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CD74 - a central player in antigen presentation by MHC class II Cluster of differentiation 74 (CD74) is an important integral membrane protein that serves as a chaperone for MHC class II molecules. CD74, also known as the invariant chain or Ii, is needed for the proper folding and trafficking of MHC class II in...    Read more.

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