Hu, Mu, Rt, Po, Bv, Fe, Mk, Rb, ShApplications:
WB, ICC/IF, IHC, IHC-P, IPHost:
WB, Flow, ICC/IF, IHC-PHost:
Species: Hu, Mu, Rt
Applications: WB, IHC, ICC
Host: Goat Polyclonal
Applications: WB, ELISA, PA
Caveolae are cholesterol/sphingolipid-rich microdomains of the plasma membrane that have been implicated in signal transduction and vesicular trafficking. Caveolins are a family of caveolae-associated integral membrane proteins (1). Caveolin, a 21- to 24-kDa integral membrane protein, is a principal component of caveolae membranes. Caveolin interacts directly with heterotrimeric guanine nucleotide binding proteins (G proteins) and can functionally regulate their activity. Caveolins 1 and 2 are similar in most respects, however, caveolin-1 and caveolin-2 differ in their functional interactions with heterotrimeric G proteins, possibly explaining why caveolin-1 and -2 are coexpressed within a single cell (2). Caveolin-2 is up-regulated in response to the mechanical injury of differentiated PC12 cells; up-regulation of caveolin-2 under these conditions is strictly dependent on continued treatment with NGF. Robust expression of caveolin-1 and -2 is also observed along the entire cell surface of DRG neurons, including high levels on growth cones. These findings demonstrate that neuronal cells express caveolins (1).
|Product By Gene ID
- caveolin 2 isoform a and b
- caveolae protein, 20-kD
- caveolin 2
Bioinformatics Tool for Caveolin-2
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