Casein Kinase 2 alpha Products

Description

Casein kinase I (also designated CKI) and casein kinase II (also designated CKII) compose a family of serine/ threonine protein kinases which are present in all eukaryotes examined to date. CKI family members, which include CKIalpha, gamma, e and delta, have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. CKII is usually expressed as a tetrameric complex consisting of either an alpha2beta2 or an alphaalpha'beta2 structure. The a catalytic subunit is stimulated by the beta regulatory subunit, which undergoes autophosphorylation. CKII activity is high in the cytosol and nucleus of proliferating and differentiating cells. CKII is known to phosphorylate more than 100 different substrates including nuclear oncoproteins, transcription factors and enzymes involved in DNA metabolism.

Bioinformatics

Entrez	116549 Rat 12995 Mouse 1457 Human
Uniprot	AAH11668 Human NM_001895 Human NM_177560 Human NP_001886 Human NP_001886.1 Human P68400 Human
Product By Gene ID	1457
Alternate Names	casein kinase 2, alpha 1 polypeptide casein kinase II alpha 1 subunit CK II alpha CK2 catalytic subunit alpha CK2A1casein kinase II subunit alpha CKII EC 2.7.11 EC 2.7.11.1 protein kinase CK2

Diseases related to Casein Kinase 2 alpha

Discover more about diseases related to Casein Kinase 2 alpha.

Malignant Neoplasms
Malignant Neoplasm Of Lung
Lung Neoplasms
Non-small Cell Lung Carcinoma
Prion Diseases
Neoplasm Metastasis
Metastatic Malignant Neoplasm To The Lymph Node
Neurodegenerative Disorders
Sequelae Aspects
Infertility
Carcinoma
Neoplasms
Hemoglobinopathies
Oligospermia
Cytogenetic Abnormality
Colorectal Cancer
Squamous Cell Lung Carcinoma
Adenocarcinoma
Neuroblastoma
Malignant Squamous Cell Neoplasm

Pathways for Casein Kinase 2 alpha

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Translation
Secretion
Cell Proliferation
Gland Development
Lactation
Osteoblast Differentiation
Cellular Process
Mammary Gland Development
Localization
Spermatogenesis
Dna Replication
Phagocytosis
Pathogenesis
Head Morphogenesis
Rna Interference

Research Areas for Casein Kinase 2 alpha

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Cancer
Cell Cycle and Replication
DNA Repair
Protein Kinase
Signal Transduction
Wnt Signaling Pathway

Bioinformatics Tool for Casein Kinase 2 alpha

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