Species: Hu, Mu, Rt, Bv, Xp
Applications: WB, ELISA, Func, ICC/IF, IHC, IP
Host: Mouse Monoclonal
Species: Hu, Mu, Rt, Rb, Ze
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ELISA, Flow, ICC/IF, IHC
Host: Goat Polyclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Mu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
Calcium/calmodulin-dependent protein kinase II (CaMKII) is a widely distributed protein kinase that regulates numerous physiological functions. Inhibitors of CaMKII are useful tools for investigating the CaMKII functions (1). The synapse contains densely localized and interacting proteins that enable it to adapt to changing inputs. A Ca2+-sensitive protein complex involved in the regulation of AMPA receptor synaptic plasticity. The complex is comprised of MUPPI, a multi-PDZ domain-containing protein; SynGAP, a synaptic GTPase-activating protein; and the Ca2+/calmodulin-dependent kinase CaMKII. In synapses of hippocampal neurons, SynGAP and CaMKII are brought together by direct physical interaction with the PDZ domains of MUPP1, and in this complex, SynGAP is phosphorylated. Ca2+CaM binding to CaMKII dissociates it from the MUPP1 complex, and Ca2+ entering via the NMDAR drives the dephosphorylation of SynGAP (2).
Bioinformatics
Entrez |
Mouse Rat Human |
Uniprot |
Human Human Human Human Rat Human |
Product By Gene ID |
815 |
Alternate Names |
- calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha
- calcium/calmodulin-dependent protein kinase II alpha
- calcium/calmodulin-dependent protein kinase II alpha-B subunit
- CaM kinase II alpha subunit
- CaM kinase II subunit alpha
- CAMKAcalcium/calmodulin-dependent protein kinase type II subunit alpha
- CaMK-II alpha subunit
- CaMK-II subunit alpha
- CaMKIINalpha
- CaM-kinase II alpha chain
- EC 2.7.11
- EC 2.7.11.17
- KIAA0968calcium/calmodulin-dependent protein kinase type II alpha chain
|