BMAL1 Products

Description

Aryl hydrocarbon receptor nuclear translocator-like (ARNTL), also known as Bmal1 or Mop3 is a major component of the circadian clock oscillator. Specifically, BMAL-1 acts as a general dimerization partner for a subset of the bHLH-PAS (basic-helix-loop-helix-PER-ARNT-SIM) superfamily of transcription regulators, is involved in circadian rhythm generation. BMAL 1 interacts with MOP4, CLOCK, Hypoxia-inducible factor-1 alpha and -2 alpha. This interaction appears to be distinct from that of the more characterized general partner, ARNT (HIF-1Beta).

BMAL1 is highly expressed in the adult brain, skeletal muscle and heart, and has been associated with hypertension and type 2 diabetes. Because of its role in the circadian clock oscillator, BMAL-1 is also thought to be invloven seasonal affective disorder. Therefore, BMAL1 antibodies are useful for circadian studies as well as heart and brain research.

Bioinformatics

Product By Gene ID

406

Alternate Names

ARNTL aryl hydrocarbon receptor nuclear translocator-like protein 1 aryl hydrocarbon receptor nuclear translocator-like basic-helix-loop-helix-PAS orphan MOP3 BHLHE5 bHLHe5brain and muscle bHLH-PAS protein JAP3 BMAL1 BMAL1c BMAL1TIC Brain and muscle ARNT-like 1 Class E basic helix-loop-helix protein 5 JAP3 Member of PAS protein 3 member of PAS superfamily 3 MOP3 MOP3BMAL1c PAS domain-containing protein 3 PASD3 PASD3MGC47515 TIC