Hu, Mu, Rt, PmApplications:
WB, ChIP, Flow, Flow-IC, ICC/IF, IHC, IHC-Fr, IHC-PHost:
WB, ICC/IF, IHC, IHC-Fr, IHC-PHost:
Applications: WB, IHC
Host: Mouse monoclonal
WB, ELISA, PA, AP
Aryl hydrocarbon receptor nuclear translocator-like (ARNTL), also known as Bmal1 or Mop3 is a major component of the circadian clock oscillator. Specifically, BMAL-1 acts as a general dimerization partner for a subset of the bHLH-PAS (basic-helix-loop-helix-PER-ARNT-SIM) superfamily of transcription regulators, is involved in circadian rhythm generation. BMAL 1 interacts with MOP4, CLOCK, Hypoxia-inducible factor-1 alpha and -2 alpha. This interaction appears to be distinct from that of the more characterized general partner, ARNT (HIF-1Beta).
BMAL1 is highly expressed in the adult brain, skeletal muscle and heart, and has been associated with hypertension and type 2 diabetes. Because of its role in the circadian clock oscillator, BMAL-1 is also thought to be invloven seasonal affective disorder. Therefore, BMAL1 antibodies are useful for circadian studies as well as heart and brain research.
|Product By Gene ID
- bHLH-PAS protein JAP3
- member of PAS superfamily 3
- Member of PAS protein 3
- basic-helix-loop-helix-PAS orphan MOP3
- Class E basic helix-loop-helix protein 5
- aryl hydrocarbon receptor nuclear translocator-like protein 1
- Brain and muscle ARNT-like 1
- bHLHe5brain and muscle
- PAS domain-containing protein 3
- aryl hydrocarbon receptor nuclear translocator-like
Bioinformatics Tool for BMAL1
Discover related pathways, diseases and genes to BMAL1. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.