Bcl G Products

Description

Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bcl-G. The mRNA of Bcl-G encodes 2 isoforms, Bcl-GL, which is widely expressed in multiple tissues, and Bcl-GS, which is only found in testis. The Bcl-GS protein is predominantly localized to cytoplasmic organelles whereas Bcl-GL was distributed throughout the cytosol. Overexpression of either protein induced apoptosis, although Bcl-GS was far more potent than Bcl-GS. Apoptosis induction was dependent on the BH3 domain and could be suppressed by co-expression with the anti-apoptotic Bcl-XL protein.

Bioinformatics

Entrez	79370 Human
Uniprot	AAH25778 Human AAH25778.1 Human NM_030766 Human NM_138722 Human NP_620048 Human NP_620048.1 Human NP_620049 Human
Product By Gene ID	79370
Alternate Names	apoptosis facilitator Bcl-2-like protein 14 Apoptosis regulator Bcl-G Bcl2-L-14 BCL2-like 14 (apoptosis facilitator) BCL-G BCLGbcl2-L-14

Research Areas for Bcl G

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Apoptosis