Bcl G Products

Description

Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bcl-G. The mRNA of Bcl-G encodes 2 isoforms, Bcl-GL, which is widely expressed in multiple tissues, and Bcl-GS, which is only found in testis. The Bcl-GS protein is predominantly localized to cytoplasmic organelles whereas Bcl-GL was distributed throughout the cytosol. Overexpression of either protein induced apoptosis, although Bcl-GS was far more potent than Bcl-GS. Apoptosis induction was dependent on the BH3 domain and could be suppressed by co-expression with the anti-apoptotic Bcl-XL protein.

Bioinformatics

Entrez	79370 Human
Uniprot	NP_620048 Human NP_620048.1 Human NP_620049 Human NM_030766 Human AAH25778 Human AAH25778.1 Human NM_138722 Human
Product By Gene ID	79370
Alternate Names	BCL-G Bcl2-L-14 Apoptosis regulator Bcl-G BCLGbcl2-L-14 apoptosis facilitator Bcl-2-like protein 14 BCL2-like 14 (apoptosis facilitator)

Diseases related to Bcl G

Discover more about diseases related to Bcl G.

Malignant Neoplasms
Neoplasms
Malignant Neoplasm Of Breast
Leukemia
Mammary Neoplasms
Acute Lymphocytic Leukemia
Deregulation Of Apoptosis
Carcinoma
Adenocarcinoma
Cell Transformation, Neoplastic
Carcinoma, Transitional Cell
Laryngeal Squamous Cell Carcinoma
Dna Injury
Malignant Neoplasm Of Larynx
Endometrial Polyp
Premature Aging Syndrome
Malignant Neoplasm Of Urinary Bladder
Malignant Neoplasm Of Lung
Sarcoma

Pathways for Bcl G

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Rna Interference
Cell Adhesion
Transport
Cell Proliferation
Programmed Cell Death
Aging
Immune Response
Ion Transport
Senescence
Drug Resistance
Mrna Splicing
Cell Cycle
Cell Death
Stress-induced Premature Senescence
Angiogenesis
Mitotic Recombination
Pathogenesis
Protein Ubiquitination
Oncogenesis

Research Areas for Bcl G

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Apoptosis

PTMs for Bcl G

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Phosphorylation
Ubiquitination

Bioinformatics Tool for Bcl G

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