Bax Products

Antibodies
Bax Antibody (6A7)
Bax Antibody (6A7)
NBP1-28566
Species: Hu, Mu, Rt
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-Fr, IP
Host: Mouse Monoclonal
Bax Antibody
Bax Antibody
NB100-56095
Species: Hu
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
Bax Antibody
Bax Antibody
NB100-56096
Species: Hu, Mu, Rt, Ge
Applications: WB, IHC, IHC-Fr, IHC-P, IP
Host: Rabbit Polyclonal
Lysates
Bax Overexpression Lysate (Na ...
Bax Overexpression Lysate (Native)
NBP2-05632
Applications: WB
Proteins
Bax Recombinant Protein
Bax Recombinant Protein
H00000581-P01
Species: Hu
Applications: WB, ELISA, PA
Bax Partial Recombinant Prote ...
Bax Partial Recombinant Protein
H00000581-Q01
Species: Hu
Applications: WB, ELISA, PA
Bax Recombinant Protein Antig ...
Bax Recombinant Protein Antigen
NBP1-88682PEP
Species: Hu
Applications: AC
RNAi
Bax RNAi
Bax RNAi
H00000581-R01
Species: Hu
Bax RNAi
Bax RNAi
H00000581-R02
Species: Hu
Bax RNAi
Bax RNAi
H00000581-R04
Species: Hu

Description

The Bcl-2 family of apoptosis-related genes plays central roles in regulating apoptotic pathways (reviewed in Thomadaki and Scorilas, 2006). Regulation of cell death through apoptosis is critical for the maintenance of homeostasis, defense against infectious agents, and normal development. Bcl-2 family proteins regulate apoptosis primarily through the regulation of mitochondrial outer membrane permeability. In mammals, the family consists of both prosurvival (antiapoptotic) and proapoptotic (prodeath) members. Cellular homeostasis is thought to be dependent on a balance between the actions of prosurvival and proapoptotic proteins. Bcl-2 family proteins can be divided into 3 main subfamilies on the basis of their function and the content of their Bcl-2 homology (BH) domains, for example: 1) Prosurvival: Bcl-2, Bcl-XL, Bcl-W, A1, and Mcl-1 2) Proapoptotic (multidomain): Bax, Bak, and Bok. 3) BH3-only (proapoptotic): Bad, Bcl-XS, Bid, Bik, Bim, Blk, Bmf, Bnip, Noxa, and Puma. Prosurvival members inhibit cells from undergoing apoptosis, whereas proapoptotic and BH3-only subfamily members promote apoptosis. There are 4 BH domains (1-4) conserved among Bcl-2 family proteins. The BH domains are important for function as well as for heterodimerization between family members. Typical prosurvival family members have all four BH domains (1-4), whereas proapoptotic (multidomain) members have BH1, 2 and 3 domains and BH3-only members have only the BH3 domain. Overall, the relative ratio of prosurvival and proapoptotic proteins determines the suseptibility of a cell to various apoptotic stimuli. Many Bcl-2 family proteins are differentially expressed in various malignancies and some are useful prognostic biomarkers. Prosurvival proteins are often elevated in diverse cancers and have the potential to confer resistance to both endogenous cell death stimuli and cancer treatments. Alterations in the ratio or levels of Bcl-2 family proteins have been also associated with nonmalignant diseases including neurodegenerative diseases, autoimmune diseases, AIDs, Down's syndrome, cardiovascular diseases, diabetes, glomerulonephritis, and muscular dystrophy. IMG-5682 recognizes Bax. It reacts with an epitope (PELALDPVPQDASTKKLSE)which is 100% conserved in human Bax isoforms alpha (192 amino acids), beta (218 amino acids), epsilon (164 amino acids), sigma (179 amino acids), and psi (173 amino acids).

Bioinformatics

Entrez Human
Mouse
Rat
Bovine
Uniprot Human
Human
Human
Human
Human
Human
Human
Human
Human
Human
Human
Mouse
Product By Gene ID 581
Alternate Names
  • Bcl2-L-4
  • Bcl-2-like protein 4
  • BCL2L4bcl2-L-4
  • apoptosis regulator BAX
  • BCL2-associated X protein

Research Areas for Bax

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Core ESC-Like Genes
Stem Cell Markers
Tumor Suppressors

Bioinformatics Tool for Bax

Discover related pathways, diseases and genes to Bax. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related Bax Blog Posts

Check out the latest blog posts on Bax.
p53 - Investigating an important tumor suppressor
p53 is a tumor suppressor that has a central role in regulating cell cycle arrest, DNA repair, and apoptosis. p53 is widely studied for its role in cancer and is mutated or altered in more than half of all cancers (1). This widespread role in tumor...    Read more.
UVRAG - A regulator of membrane trafficking in autophagy and endocytosis
UV resistance-associated gene (UVRAG) is a tumor suppressor that is commonly mutated in colon and breast cancer. While UVRAG was discovered for its ability to complement UV sensitivity in xeroderma pigmentosum cells, its main functions are in auto...    Read more.
Caspase 9: The Suicidal Cell Whisperer
Cell death via apoptosis is a key cellular function triggered by the cell death receptor family and their ligands which signal through downstream adaptor molecules and the caspase protease family. Among the subclass of initiator caspases that include...    Read more.
Dynamin-related Protein 1 (DRP1) in Mitochondria and Apoptosis.
Dynamin-related Protein 1 (DRP1) is known to function in mitochondrial and peroxisomal division and mediate membrane fission through oligomerization into ring-like structure and sever the mitochondrial membrane, through a GTP hydrolysis-dependent mech...    Read more.
Ku70's Roles in Double Strand and Mismatch DNA Repair
Ku70 is a 70 kDa protein that was shown to be involved in multiple cellular pathways, mainly involving DNA repair and recombination. Among these are the non-homologus end repairs of DNA double strand breaks. Ku70 was first identified as an autoantigen...    Read more.
Bax Research Gives New Insight into Oxidative Apoptosis
Bax is a member of the Bcl-2 family; an extensive range of proteins which play key roles in apoptosis, or programmed cell death, by regulating outer mitochondrial membrane permeability. We at Novus Biologicals are one of the leading antibody suppliers...    Read more.
Read more Bax related blogs.