Aromatase Products

Antibodies
Aromatase Antibody
Aromatase Antibody
NBP1-19697
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Aromatase Antibody (H4)
Aromatase Antibody (H4)
NBP2-33336
Species: Hu, Mu, Rt, Po, Bv, Ch, Pm, Rb, Sh
Applications: WB, IHC, IHC-P
Host: Mouse Monoclonal
Lysates
Aromatase Overexpression Lysa ...
Aromatase Overexpression Lysate (N...
NBL1-09674
Applications: WB
Aromatase Overexpression Lysa ...
Aromatase Overexpression Lysate (N...
NBP2-11585
Applications: WB
Aromatase Overexpression Lysa ...
Aromatase Overexpression Lysate (D...
H00001588-T02
Applications: WB
Proteins
Aromatase Peptide
Aromatase Peptide
NB100-1596PEP
Species: Hu
Aromatase Recombinant Protein ...
Aromatase Recombinant Protein
H00001588-P01
Species: Hu
Applications: WB, ELISA, PA
Aromatase Recombinant Protein ...
Aromatase Recombinant Protein
H00001588-P03
Species: Hu
Applications: WB, ELISA, PA
RNAi
Aromatase RNAi
Aromatase RNAi
H00001588-R02
Species: Hu
Aromatase RNAi
Aromatase RNAi
H00001588-R01
Species: Hu

Description

Aromatase is a member of the cytochrome P450 superfamily, whose function is to produce estrogens by aromatizing androgens. The primary function of Aromatase is to convert androstenedione to estrone and testosterone to estradiol. This protein is also a key enzyme in steroidogenesis, specifically for the biosynthesis of estrogens. Because estrogens also promote certain cancers and other diseases, aromatase inhibitors are frequently used to treat such diseases. It also plays an important role in sexual differentiation, fertility, and carcinogenesis.

Aromatase is localized in the endoplasmic reticulum of the cell and its activity is regulated by tissue specific promoters that are in turn controlled by hormones, cytokines, and other factors. It can be found in many tissues reproductive tissues including gonads, brain, adipose tissue, placenta, blood vessels, skin, bone, endometrium as well as in tissue of endometriosis, uterine fibroids, breast cancer, and endometrial cancer.

Many environmental chemicals may influence aromatase activity and thereby disrupt endocrine function. The activity is increased by environmental factors such as age, obesity, insulin, gonadotropins, and alcohol but decreased by prolactin, anti-m llerian hormone, and smoking.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 1588
Alternate Names
  • Estrogen synthase
  • Aromatase
  • Cytochrome P-450AROM
  • microsomal monooxygenase
  • AROsubfamily XIX (aromatization of androgens)
  • CYARMGC104309
  • ARO1EC 1.14.14.1
  • CYPXIX
  • cytochrome P450, family 19, subfamily A, polypeptide 1

Research Areas for Aromatase

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
Cell Biology
Cell Cycle and Replication
Chromatin Research
Innate Immunity
Lipid and Metabolism
Neuroscience

PTMs for Aromatase

Learn more about PTMs related to Aromatase.

Phosphorylation
Cleavage
Methylation
Hydroxylation
Deacetylation
Glycosylation
Acetylation
Oxidation

Bioinformatics Tool for Aromatase

Discover related pathways, diseases and genes to Aromatase. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related Aromatase Blog Posts

Check out the latest blog posts on Aromatase.
Aromatase - A Key Enzyme in the Biosynthesis of Estrogens
The enzyme, aromatase, belongs to cytochrome P450 family of monooxygenases known for their key role in drug catabolism and cholesterol/steroid synthesis. Aromatase uses a heme-group as a co-factor to catalyze the formation of aromatic C18 estrogens fr...    Read more.
Read more Aromatase related blogs.