Angiopoietin-4 Products

Description

Angiopoietin 3 (ANG3), also called ANG4, might represent counterparts in mouse and human. Based on chromosomal analysis, mouse ANG3 is thought to be an ortholog of human ANG4. Human ANG4 acts as an agonist that binds and activates Tie2, whereas mouse ANG3 is likely to be a Tie2 antagonist, exerting agonist or antagonist activities depending on the cell context. Mouse ANG3 is expressed in various mouse tissues. Mouse angiopoietin 3 is a secreted glycoprotein and member of the angiopoietin family. It has an N terminal coiled-coil domain and a Cbterminal fibrinogen like domain. The coiled coil domains mediate ligand homo oligomerization and the fibrinogen like domains mediate ligand activity. Recombinant mouse angiopoietin 3 has a calculated molecular mass of 58 kDa. Due to glycosylation, the recombinant protein (containing 3 peptides) has an apparent molecular mass of 85-90 kDa in SDS-PAGE under reducing conditions. Mouse angiopoietin 3 shares 47%, 46%, and 54% sequence identity with mouse ANG1, mouse ANG2, and human ANG4, respectively.

Bioinformatics

Entrez	51378 Human
Uniprot	NM_015985 Human NP_057069 Human Q9Y264 Human
Product By Gene ID	51378
Alternate Names	AGP4 ANG3 ANG-3 ANG-4 ANG4angiopoietin-3 angiopoietin 4 Angiopoietin-3 angiopoietin-4 dJ824F16.2 (angiopoietin 4) MGC138181 MGC138183

Diseases related to Angiopoietin-4

Discover more about diseases related to Angiopoietin-4.

Tumor Angiogenesis
Inflammation
Dyslipidemias
Melanoma
Dementia
Hyperlipoproteinemia Type Iib
Hypercholesterolemia, Familial
Endometrial Polyp
Hypoxia
Inflammatory Response
Insulin Resistance
Dementia, Vascular
Malignant Neoplasms
Neoplasms
Rheumatoid Arthritis
Pathologic Neovascularization
Psoriasis
Chronic Inflammation

Pathways for Angiopoietin-4

View related products by pathway and learn more about each of the pathways below.

Angiogenesis
Methylation
Decidualization
Reverse Transcription
Cytokine Production
Dna Methylation
Wound Healing
Inflammatory Response
Secretion

PTMs for Angiopoietin-4

Learn more about PTMs related to Angiopoietin-4.

Phosphorylation
Methylation

Bioinformatics Tool for Angiopoietin-4

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